Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification
Huan Zhong, Xiaopu Zhou, Hyebin Uhm, Yuanbing Jiang, Han Cao, Yu Chen, Tiffany T. W. Mak, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Y. Mok, Andrew Lung Tat Chan, Timothy C. Y. Kwok, Vincent C. T. Mok, Fanny C. F. Ip, John Hardy, Amy K. Y. Fu, Nancy Y. Ip Alzheimers Dement. 2024 Feb 7. doi: 10.1002/alz.13691. [Abstract] [Full text]
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.
Yuanbing Jiang, Hyebin Uhm, Fanny C. Ip, Li Ouyang, Ronnie M. N. Lo, Elaine Y. L. Cheng, Xiaoyun Cao, Clara M. C. Tan, Brian C. H. Law, Paula Ortiz-Romero, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Kin Y. Mok, John Hardy, Timothy C. Y. Kwok, Vincent C. T. Mok, Marc Suárez-Calvet, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip Alzheimers Dement. 2024 Jan 6. doi: 10.1002/alz.13676. PMID: 38183344 [Abstract] [Full text]
Lau S.F., Wu W., Wong H.Y., Ouyang L., Qiao Y., Xu J., Lau H.Y.J., Wong C., Jiang Y., Holtzman D.M., Fu A.K.Y. and Ip N.Y. Nature Aging 2023 Sep 21. doi: 10.1038/s43587-023-00491-1. [Abstract] [Full text]
Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping
Qin Z., She Z., Chen C., Wu W., Lau J.K.Y., Ip N.Y., Qu J.Y. Nat Biotechnol. 2022 Jun 13. doi: 10.1038/s41587-022-01343-w. PMID: 35697805 [Abstract] [Full text]
Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology
Park J.C., Barahona-Torres N., Jang S.Y., Mok K.Y., Kim H.J., Han S.H., Cho K.H., Zhou X., Fu A.K.Y., Ip N.Y., Seo J., Choi M., Jeong H., Hwang D., Lee D.Y., Byun M.S., Yi D., Han J.W., Mook-Jung I., Hardy J. Adv Sci (Weinh). 2022 Jun 13;e2201212. doi: 10.1002/advs.202201212 [Abstract] [Full text]
Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk
Cao H., Zhou X., Chen Y., Ip F.C.F., Chen Y., Lai N.C.H., Lo R.M.N., Tong E.P.S., Mok V.C.T., Kwok T.C.Y.; Alzheimer’s Disease Neuroimaging Initiative, Fu A.K.Y., Ip N.Y. J Alzheimers Dis. 2022;86(4):1861-1873. doi: 10.3233/JAD-215311. PMID: 35253752 [Abstract] [Full text]
Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong
Wong H.Y., Zhong H., Zhong M., Zhou X., Chan P.Y.C., Kwok T.C.Y., Mok K., Hardy J., Ip F.C.F., Fu A.K.Y., Ip N.Y. J Alzheimers Dis. 2022 Apr 16. doi: 10.3233/JAD-215312. PMID: 35466936 [Abstract] [Full text]
2021
Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y. Alzheimers Dement. 2021 Dec;17 Suppl 3:e056625. doi: 10.1002/alz.056625. PMID: 35109110 [Abstract] [Full text]
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
Goertsen D., Flytzanis N.C., Goeden N., Chuapoco M.R., Cummins A., Chen Y., Fan Y., Zhang Q., Sharma J., Duan Y., Wang L., Feng G., Chen Y., Ip N.Y., Pickel J., Gradinaru V. Nat Neurosci. 2021 Dec 9. doi: 10.1038/s41593-021-00969-4. PMID: 34887588 [Abstract] [Full text]
A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D
Wu M.Y., Wong A.Y.H., Leung J.K., Kam C., Wu K.L., Chan Y.S., Liu K., Ip N.Y. and Chen S. Proc Natl Acad Sci U S A; 2021 Nov 9;118(45):e2106143118. doi: 10.1073/pnas.2106143118. PMID: 34740969 [Abstract] [Full text]
Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model
Fu W.Y., Hung K.W., Lau S.F., Butt B., Yuen V.W., Fu G., Chan I.C., Ip F.C.F., Fu A.K.Y. and Ip N.Y. ACS Chem Neurosci. 2021 Nov 5. doi: 10.1021/acschemneuro.1c00600. PMID: 34738783 [Abstract] [Full text]
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice
Ip F.C.F., Fu G., Yang F., Kang F., Sun P., Ling C.Y., Cheung K., Xie F., Hu Y., Fu L. and Ip N.Y. Eur J Med Chem. 2021 Sep 13;226:113827. doi: 10.1016/j.ejmech.2021.113827. PMID: 34530383 [Abstract] [Full text]
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Duan Y., Ye T., Qu Z., Chen Y., Miranda A., Zhou X., Lok K.C., Chen Y., Fu A.K.Y., Gradinaru V. and Ip N.Y. Nat Biomed Eng. 2021 Jul 26. doi: 10.1038/s41551-021-00759-0.PMID: 34312508 [Abstract] [Full text]
IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry
Wang Y., Fu A.K.U. and Ip N.Y. DNA Cell Biol. 2021 Jul 22. doi: 10.1089/dna.2021.0491. [Abstract]
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease
Xu P., Chang J.C., Zhou X., Wang W., Bamkole M., Wong E., Bettayeb K., Jiang L.L., Huang T., Luo W., Xu H., Nairn A.C., Flajolet M., Ip N.Y., Li Y.M., Greengard P. J Exp Med. 2021 Aug 2;218(8):e20202446. doi: 10.1084/jem.20202446. [Abstract] [Full text]
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging
Jiang Y., Zhou X., Ip F.C., Chan P., Chen Y., Lai N.C.H., Cheung K., Lo R.M.N., Tong E.P.S., Wong B.W.Y., Chan A.L.T., Mok V.C.T., Kwok T.C.Y., Mok K.Y., Hardy J., Zetterberg H., Fu A.K.Y. and Ip N.Y. Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12369. [Abstract] [Full text]
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
Lau S.F., Chen C., Fu W.Y., Qu J.Y., Cheung T.H., Fu A.K.Y. and Ip N.Y. Cell Rep. 2020 Apr 21;31(3):107530. doi: 10.1016/j.celrep.2020.107530. [Abstract] [Full text]
Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model
Lau J.K.Y., Tian M., Shen Y., Lau S.F., Fu W.Y., Fu A.K.Y. and Ip N.Y. Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4. [Abstract] [Full text]
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
Ye T., Duan Y., Tsang H.W.S., Chen Y., Cao H., Chen Y., Fu A.K.Y. and Ip N.Y. Communications Biology 4, Article number: 195 (2021) [Abstract] [Full text]
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
Lau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y. STAR Protocols STAR Protoc. 2021 Jan 13;2(1):100265. doi: 10.1016/j.xpro.2020.100265. eCollection 2021 Mar 19. [Abstract] [Full text]
Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
Wang Y., Fu W.Y., Cheung K., Hung K.W., Chen C., Geng H., Yung W.H., Qu J.Y., Fu A.K.Y. and Ip N.Y. Proc. Natl. Acad. Sci. USA. January 5, 2021 118 (1) e2020810118; https://doi.org/10.1073/pnas.2020810118 [Abstract] [Full text]
Luo W., Ip F.C.F., Fu G., Cheung K., Tian Y., Hu Y., Sinha A., Cheng E.Y.L., Wu X., Bustos V., Greengard P., Li Y.M., Sinha S.C., and Ip N.Y. ACS Chem Neurosci. 2020 Aug 10. doi: 10.1021/acschemneuro.0c00389. [Abstract] [Full text]
Zhou X., Chen Y., Ip F.C.F., Lai N.C.H., Li Y.Y.T., Jiang Y., Zhong H., Chen Y., Zhang Y., Ma S., Lo R.M.N., Cheung K., Tong E.P.S., Ko H., Shoai M., Mok K.Y., Hardy J., Mok V.C.T., Kwok T.C.Y., Fu A.K.Y. and Ip N.Y. Alzheimers Dement (Amst). 2020 Aug 5;12(1):e12074. doi: 10.1002/dad2.12074. eCollection 2020. [Full text] [Full text]
Lau S.F., Chen C., Fu W.Y., Qu Y., Cheung T.H.T., Fu A.K.Y. and Ip N.Y. Cell Reports 2020 Apr 21; (31)107530. doi.org/10.1016/j.celrep.2020.107530 [Abstract] [Full text]
Zhou X., Chen Y., Mok K.Y., Kwok T.C.Y., Mok V.C.T., Guo Q., Ip F.C.F., Chen Y., Mullapudi N.; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P., Sullivan P.F., Hardy J., Fu A.K.Y., Li Y. and Ip N.Y. Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z. [Abstract] [Full text]
α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis
Su Y., Lau S.F., Ip J.P.K., Cheung K., Cheung T.H.T. , Fu A.K.Y. and Ip N.Y. Proc. Natl. Acad. Sci. USA. 2019 Jun 17. pii: 201903891. doi: 10.1073/pnas.1903891116. [Abstract] [Full text]
Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect
Chen W.-W., Fu W.Y., Su Y., Fang W.-Q., Fu A.K.Y. and Ip N.Y. Sci. Rep. 2019 Feb 4;9(1):1190. doi: 10.1038/s41598-018-38103-3. [Abstract] [Full text]
2018
In Vivo near-infrared two-photon imaging of amyloid plaques in deep brain of Alzheimer’s Disease mouse model
Chen C., Liang Z., Zhou B., Li X., Lui C., Ip N.Y. and Qu J. ACS Chem. Neurosci. DOI: 10.1021/acschemneuro.8b00306 Publication Date (Web): August 1, 2018 [Abstract] [Full text]
Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses
Ng Y.P., Yip T.F., J.S. Malik Peiris, Ip N.Y. and Lee M.Y. Suki Journal of NeuroVirology 2018 Jul 9. doi: 10.1007/s13365-018-0659-8. [Abstract]
Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs
Gu S., Fu W.Y., Fu A.K.Y., Tong E.P.S., Ip F.C.F., Huang X. and Ip N.Y. Scientific Reports 2018 May 9;8(1):7377. doi: 10.1038/s41598-018-25790-1. [Full text] [Full text]
Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex–nucleus accumbens pathway in mice
Cui Q., Li Q., Geng H., Chen L., Ip N.Y., Ke Y., and Yung W.H. Proc. Natl. Acad. Sci. USA. 2018 May 22;115(21):E4890-E4899. doi: 10.1073/pnas.1717106115. Epub 2018 May 7. [Full text] [Full text]
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
Zhou X., Chen Y., Mok K.Y., Zhao Q., Chen K., Chen Y., Hardy J., Li Y., Fu A.K.Y., Guo Q., Ip N.Y. and for the Alzheimer’s Disease Neuroimaging Initiative Proc. Natl. Acad. Sci. USA. February 20, 2018. 115 (8) 1697-1706; published ahead of print February 5, 2018; https://doi.org/10.1073/pnas.1715554115. [Full text] [Full text]
2017
A new iridoid glycoside and a new cinnamoyl glycoside from Scrophularia ningpoensis Hemsl
Zhang J., Ip F.C.F., Liang Y., Ip N.Y., Zhong B., Lai C.W., Xu S. Nat Prod Res. 2017 Oct;31(20):2361-2368. doi: 10.1080/14786419.2017.1306704. Epub 2017 Mar 22. [Abstract]
Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses
Ng Y.P., Yip T.F., J.S. Malik Peiris, Ip N.Y. and Lee M.Y. Suki Journal of NeuroVirology 2018 Jul 9. doi: 10.1007/s13365-018-0659-8. [Abstract]
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development
Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y. Proc Natl Acad Sci USA. August 15, 2017. 114 (33) E6992-E7001; published ahead of print July 31, 2017. https://doi.org/10.1073/pnas.1708240114 [Full text] [Full text]
Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response
Ip F.C.F., Ng Y.P., Or C.T.T., Sun P., Fu G., Li Y.H.J., Ye W., Cheung T.H. and Ip N.Y. PLoS One. 2017 Jul 31;12(7):e0182069. doi: 10.1371/journal.pone.0182069. eCollection 2017. [Full text] [Full text]
Diarylheptanoids from Rhizomes of Alpinia officinarum inhibit aggregation of alpha-synuclein
Fu G., Zhang W., Du D., Ng Y.P., Ip F.C.F., Tong R. and Ip N.Y. J Agric Food Chem. 2017 Jul 14. doi: 10.1021/acs.jafc.7b02021. [Abstract] [Full text]
Two pairs of unusual melibiose and raffinose esters from Scrophularia ningpoensis
Zhang J., Liang Y., Ip F.C.F., Ip N.Y., Liu T., Zhong B. and Xu S. J Asian Nat Prod Res. 2017 May 24:1-8. doi: 10.1080/10286020.2017.1329301.
An Y., Wang G., Diao Y., Long Y., Fu X., Weng M., Zhou L., Sun K., Cheung T.H., Ip N.Y., Sun H., Wang H. and Wu Z. Dev Cell. 2017 May 22;41(4):382-391.e5. doi: 10.1016/j.devcel.2017.04.012. [Abstract]
2016
Stimulation of the hippocampal POMC/MC4R circuit alleviates synaptic plasticity impairment in an Alzheimer's Disease model
Shen Y., Tian M., Zheng Y., Gong F., Fu A.K.Y. and Ip N.Y. Cell Rep. 2016 Nov 8;17(7):1819-1831. doi: 10.1016/j.celrep.2016.10.043. [Abstract] [Full text]
Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats
Ip F.C.F., Zhao Y., Chan K.W., Cheng E.Y., Tong E.P., Chandrashekar O., Fu G., Zhao Z. and Ip N.Y. BMC Complement Altern Med. 2016 Nov 4;16(1):437 DOI 10.1186/s12906-016-1417-1 [Abstract] [Full text]
China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing
Poo M., Du J., Ip N.Y., Xiong Z., Xu P. and Tan T. Neuron 2016 Nov 2;92(3):591-596. doi: 10.1016/j.neuron.2016.10.050 [Abstract] [Full text]
The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
Liang Z., Zhan Y., Shen Y., Wong C.C., Yates J.R. 3rd, Plattner F., Lai K.O. and Ip N.Y. Nat. Commun. 7:13282, doi:10.1038/ncomms13282 [Abstract] [Full text]
Worldwide initiatives to advance brain research
Grillner S., Ip N.Y., Koch C., Koroshetz W., Okano H., Polachek M., Poo M. and Sejnowski T. Nat. Neurosci. 19, 1118–1122 (2016) doi:10.1038/nn.4371 [Full text] [Full text]
Design and synthesis of dimeric securinine analogs with neuritogenic activities
Tang G., Liu X., Ma N., Huang X., Wu Z.L., Zhang W., Wang Y., Zhao B., Wang Z., Ip F.C.F., Ip N.Y., Ye W.C., Shi L. and Chen W.M. ACS Chem Neurosci. July 28, 2016 doi: 10.1021/acschemneuro.6b00188 [Full text] [Full text]
STAT3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration
Zhu H., Xiao, F., Wang G., Wei X., Jiang L., Chen Y., Zhu L., Wang H., Diao Y., Wang H., Ip N.Y., Cheung T.H., and Wu Z. Cell Reports 2016 Aug 10. pii: S2211-1247(16)30959-7. doi: 10.1016/j.celrep.2016.07.041 [Abstract] [Full text]
New lignans with neuroprotective activity from Adelostemma gracillimum
Zhang J., Guo S., Chan K.W., Tong E.P.S., Fu G., Mu Q., Ip F.C.F. and Ip N.Y. Phytochem. Let. 19 (9): 1-5. [Full text] [Full text]
Multicolor 4D fluorescence microscopy using Ultrathin Bessel Light Sheets
Zhao T., Lau S.C., Wang Y., Su Y., Wang H., Cheng A., Herrup K., Ip N.Y., Du S. and Loy M.M. Science Report 2016 May 18;6:26159. doi: 10.1038/srep26159. [Full text] [Full text]
IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline
Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y. Proc Natl Acad Sci USA. May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016. https://doi.org/10.1073/pnas.1604032113 [Full text] [Full text] [F1000 Prime Recommended]
2015
Cdk5 regulates activity-dependent gene expression and dendrite development
Liang Z., Ye T., Zhou X., Lai, K.O., Fu A.K.Y. and Ip N.Y. J. Neurosci. 11 November 2015, 35(45): 15127-15134; doi: 10.1523/JNEUROSCI.1443-15.2015 [Abstract] [Full text]
Axin regulates dendritic spine morphogenesis through Cdc42-dependent signaling
Chen Y., Liang Z., Fei E., Chen Y., Zhou X., Fang W., Fu W.Y., Fu A.K.Y. and Ip N.Y. PLoS One 2015 Jul 23;10(7):e0133115. doi: 10.1371/journal.pone.0133115. [Abstract] [Full text] [F1000 Prime Recommended]
Highly trans-selective arylation of Achmatowicz rearrangement products by reductive γ-Deoxygenation and Heck-Matsuda reaction: asymmetric total synthesis of (-)-musellarins A-C and their analogues
Li Z., Ip F.C.F., Ip N.Y. and Tong R. Chemistry 2015 Jun 24. doi: 10.1002/chem.201501713. [Abstract] [Full text]
Cdk5-dependent phosphorylation of p70 ribosomal S6 Kinase (S6K) is required for dendritic spine morphogenesis
Lai K.O., Liang Z., Fei E.,Huang H., and Ip N.Y. J Biol Chem. 2015 Apr 22. doi: 10.1074/jbc.M114.627117 [Abstract] [Full text]
NRC-interacting factor directs neurite outgrowth in an activity-dependent manner
Zhao X.S., Fu W.Y., Hung K.W., Chien W.W.Y., Li Z., Fu A.K.Y. and Ip N.Y. Neuroscience 2015 Mar 19;289:207-13. doi:10.1016/j.neuroscience.2014.12.041 [Abstract] [Full text]
Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection
Ip F.C.F., Fu W.Y., Cheng E.Y.L., Tong E.P.S., LOK K.C., Liang Y., Ye W.-C. and Ip N.Y. Neuropsychopharmacology 2015 Feb 4. doi:10.1038/npp.2015.37 [Abstract] [Full text]
2014
Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Fang W.-Q., Chen W.-W., Jiang L., Liu K., Yung W.H., Fu A.K.Y. and Ip N.Y. Cell Rep. 9(5):1635-43 [Abstract] [Full text]
p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1)
Zhao X., Fu W.Y., Chien W.W.Y., Li Z., Fu A.K.Y. and Ip N.Y. PLoS One 2014 Oct 16;9(10):e110584. doi: 10.1371/journal.pone.0110584. eCollection 2014. [Abstract] [Full text]
Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management
Ip F.C.F., Ng Y.P., An H.J., Dai Y., Pang H.H., Hu Y.Q., Chin A.C., Harley C.B., Wong Y.H. and Ip N.Y. Neurosignals 2014;22(1):52-63. doi: 10.1159/000365290. Epub 2014 Jul 31. [Abstract] [Full text]
Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex
Ye T., Ip J.P., Fu A.K.Y. and Ip N.Y. Nat. Commun. 5:4826. doi: 10.1038/ncomms5826 [Abstract] [Full text]
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease
Melanocortin-4 receptor regulates hippocampal synaptic plasticity through PKA-dependent mechanism
Shen Y., Fu, W.Y., Cheng E.Y.L., Fu A.K.Y. and Ip N.Y. J. Neurosci. 33(2):464-472. [Abstract] [Full text]
2012
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory
Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y. Nat. Neurosci. 15:1506-1515 [Highlighted in F1000Prime] [Highlighted in News and Views of Nat. Neurosci.] [Abstract] [Full text] [F1000 Prime Recommended]
Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development
Chen Y., Fu W.Y., Ip J.P., Ye T., Fu A.K.Y., Chao M.V. and Ip N.Y. J. Neurosci. 32:8263-9. [Abstract] [Full text]
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2
Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y. and Ip N.Y. Nat. Neurosci. 15:39-47. [Highlighted in F1000Prime] [Abstract] [Full text] [F1000 Prime Recommended]
2011
Cdk5-mediated phosphorylation of axin directs axon formation during cerebral cortex development
Fang W.-Q., Ip J.P., Li R., Ng Y.P., Lin S-C, Chen Y., Fu A.K.Y. and Ip, N.Y. J. Neurosci. 31(38):13613-24. [Abstract] [Full text]
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y. Nat. Neurosci. 14: 181-9. [Featured in News and Views of Nat. Neurosci.] [Abstract] [Full text]
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H. and Ip N.Y. Nat. Cell Biol. 13:568-579. [Abstract] [Full text]
2010
S-nitrosylation of cyclin-dependent kinase 5 (Cdk5) regulates its kinase activity and dendrite growth during neuronal development
Zhang P., Yu P-C, Tsang A.H.K., Chen Y, Fu A.K.Y., Fu W.Y., Chung, K.K. and Ip N.Y. J. Neurosci. 30(43):14366-14370. [Abstract] [Full text]
Wan, J., Fu A.K.Y., Ip F.C.F., Ng H.K., Hugon J., Page G., Wang J.H., Lai K.O., Wu Z. and Ip N.Y. J. Neurosci. 30(20): 6873-6881. [Highlighted in Alzheimer Research Forum] [Abstract] [Full text]
Two Cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components
Ou C.Y., Poon V.Y., Maeder C.I., Watanabe S., Lehrman E.K., Fu A.K.Y., Park M., Fu W.Y., Jorgensen E.M., Ip N.Y., and Shen K. Neuron 65: 204–216. [Abstract] [Full text]
Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction
Multiple Gi proteins participate in nerve growth factor-induced activation of c-jun N-terminal kinases in PC12 cells
Tso P.H., Morris C.J., Yung L.Y., Ip N.Y., and Wong Y.H. Neurochemical Research 34: 1101-1112. [Abstract] [Full text]
Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK
Hui K.P.Y., Lee S.M.Y., Cheung C.Y., Ng I.H.Y., Poon L.L.M., Guan Y., Ip N.Y., Lau A.S.Y., and Peiris, M.J.S. J. Immunol. 182:1088-1098. [Abstract] [Full text]
Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation
Ng Y.P., Wu Z., Wise, H., Tsim K.W.K., Wong Y.H., and Ip N.Y. NeuroSignals 17: 111-120. [Abstract] [Full text]
Identification of retinoic acid-regulated nuclear matrix-associated protein (RAMP) as a novel regulator of gastric cancer
Li J.J., Ng E.K., Ng Y.P., Wong C.Y.P., Yu J., Jin H.C., Cheng V.Y.Y., Go M.Y.Y., Cheung P.K.F., Man E.P.S., Ebert, M.P.A., Chan F.K.L. Sung J.J.Y., Ip N.Y., and Leung W.K. British Journal of Cancer 101: 691-698 [Abstract] [Full text]
Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages
Lee S., Gardy, J., Cheung C.Y., Cheung T., Hui K., Ip N.Y., Guan Y., Hancock, R., and Peirs, J.S. PLoS ONE 4(12): e8072 [Abstract] [Full text]
2008
Recent development in the search for effective antidepressants using traditional Chinese medicine
Pang T.H.H., Ip F.C.F. and Ip N.Y. Central Nervous System Agents in Medicinal Chemistry 8:64-71. [Abstract]
Hyper-induction of COX-2 mediated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1
Lee S.M.Y., Cheung C.Y., Nicholls, J.M., Hui K.P.Y., Leung C.Y.H., Uiprasertkul, M., Tipoe, G.L., Lau Y.L., Poon L.L.M., Ip N.Y., GuanY., and Peiris, M.J.S. J. Infectious Disease 198: 525-535. [Abstract] [Full text]
Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2
Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay
Pan Q., Ip F.C.F., Ip N.Y., Zhu H. and Min Z. J. Nat. Prod. 67: 1548-1551. [Abstract] [Full text]
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription
Li Z., David, G., Hung K.W., DePinho, R.A., Fu A.K.Y. and Ip, N.Y. J. Biol. Chem. 279: 54438-54444. [Abstract] [Full text]
Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression
Lai K.O., Chen Y., Po H.-M., Lok K.C., Gong K. and Ip N.Y. J. Biol. Chem. 279: 13383-13392. [Abstract] [Full text]
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
Fu A.K.Y., Fu W.Y., Ng A.K.Y., Chien W.W.Y., Ng Y.P., Wang J. and Ip N.Y. Proc. Natl. Acad. Sci. USA 101: 6728-6733. [Abstract] [Full text]
2003
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free association among components of the CNTF receptor complex
Man, D., He W., Sze K.H., Gong K., Smith, D.K., Zhu G., and Ip N.Y. J. Biol. Chem. 278: 23285-23294. [Abstract] [Full text]
Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation
Xu Z., Lai K.O., Zhou H.M., Lin S.C. and Ip N.Y. J. Biol. Chem. 278: 24767-24775. [Abstract] [Full text]
2002
Induction of Cdk5 activity in rat skeletal muscle after nerve injurys
Fu W.Y., Fu A.K.Y., Lok K.C., Ip F.C.F. and Ip N.Y. NeuroReport 13: 243-247. [Abstract]
Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro
He W., Gong K., Zhu G., Smith, D.K. and Ip N.Y. FEBS Letters 514: 214-218. [Abstract] [Full text]
Expression of Cdk5 and its activators in NT2 cells during neuronal differentiation
Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction
Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H. and Ip N.Y. Nat. Neurosci. 4: 374-381. [Abstract] [Full text]
Cloning and expression of a novel nuclear matrix associated protein that is regulated during the retinoic acid induced neuronal differentiation
Cheung W.M.W., Chu A.H., Chu P.W.K. and Ip N.Y. J. Biol. Chem. 276: 17083-17091. [Abstract] [Full text]
Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction
Lai K.O., Ip F.C.F., Cheung J., Fu A.K.Y. and Ip N.Y. Mol. Cell. Neurosci. 17: 1034-1047. [Abstract] [Full text]
Surface characterization of a silicon-based DNA microarray
Lenigk, R., Carles, M., Ip N.Y. and Sucher, N.J. Langmuir 17: 2497-2501. [Abstract]
Expression of P2Y1 nucleotide receptors in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptors
Choi R.C.Y., Man M.L.S., Ling K., Ip N.Y., Simon, J., Barnard, E.A. and Tsim K.W.K. J. Neurosci. 21: 9224-9234. [Abstract] [Full text]
Overexpression of muscle specific kinase increases the transcription and aggregation of acetylcholine receptors in Xenopus embryos
Fu A.K.Y., Cheung J., Xie P., Smith F.D. and Ip N.Y. Mol. Brain Res. 96: 21-29. [Abstract] [Full text]
Complete 1H, 15N and 13C assignments of the carboxylterminal domain of the ciliary neurotrophic factor receptor (CNTFR)
Man, D., Xia Y., Sze K.H., Smith D., He W., Ip N.Y. and Zhu G. J. Biomolecular NMR 22: 95-96. [Abstract]
2000
Synergistic effects of muscarinic agonists and secretin or vasoactive intestinal peptide on the regulation of tyrosine hydroxylase activity in sympathetic neurons
Induction of TrkA receptor by retinoic acid in leukemia cell lines
Xie P., Cheung W.M.W., Ip F.C.F., Ip N.Y. and Leung, M.F. NeuroReport 8: 1067-1070. [Abstract]
Chick muscle expresses various ARIA isoforms: Regulation during development, denervation and regeneration
Ng Y.P., Pun S., Ip F.C.F., Ip N.Y. and Tsim K.W.K. Mol. Cell. Neurosci. 9: 132-143. [Abstract] [Full text]
Agrin-deficient myotube retains its AChR aggregation ability when challenged with agrin
Pun S., Ng Y.P., Yan, J.F., Ip N.Y. and Tsim K.W.K. J. Neurochem 69: 2555-2563. [Abstract] [Full text]
Muscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures
Fu A.K.Y., Ip F.C.F., Lai K.O., Tsim K.W.K. and Ip N.Y. NeuroReport 8: 3895-3900. [Abstract]
1996
Induction of trk receptors by retinoic acid in a human embryonal carcinoma cell line
Cheung W.M.W., Chu A.H., Leung M.F. and Ip N.Y. NeuroReport 7: 1204-1208. [Abstract]
Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury
Ip F.C.F., Fu A.K.Y., Tsim K.W.K. and Ip N.Y. J. Neurochem. 67: 1607-1612. [Abstract] [Full text]
Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras
Lai K.O., Glass, D.J., Yancopoulos, G.D. and Ip N.Y. J. Neurosci. Res. 46: 618-629. [Abstract] [Full text]
1995
Binding characteristics of ciliary neurotrophic factor to sympathetic neurons and neuronal cell lines
Wong V., Pearsall, D., Arriaga R., Ip N.Y., Stahl N., and Lindsay, R.M. J. Biol. Chem. 270: 313-318. [Abstract] [Full text]
Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor
Valenzuela, D.M., Rojas E., Le Beau, M.M., Espinosa III., R., Brannan, C.I., McClain, J., Masiakowski, P., Ip N.Y., Copeland, N.G., Jenkins, N.A., and Yancopoulos, G.D. J. Biol. Chem. 270: 313-318. [Abstract] [Full text]
Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum
Asada H., Ip N.Y., Pan, L., Razack, N., Parfitt, M.M. and Plunkett, R.J. J. Neurosci. Res. 40: 22-30. [Abstract] [Full text]
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family
Valenzuela, D.M., Rojas, E., Griffiths, J.A., Compton, D.L., Gisser, M., Ip N.Y., Goldfarb, M. and Yancopoulos, G.D. Oncogene 10: 1573-1580.
Identification of mammalian noggin and its expression in the adult nervous syste
Valenzuela, D.M., Economides, A.N., Rojas, E., Lamb, T.M., Nunes, L., Jones, P., Ip N.Y., Espinosa, III, R., Brannan, C.I., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Le Beau, M.M., Harland, R.M. and Yancopoulos, G.D. J. Neurosci. 15: 6077-6084. [Full text]
Neurotrophin-3 augments steroid secretion by hamster ovarian follicles
Waraksa, J.A., Lindsay, R.M., Ip N.Y. and Hutz, R.J. in vitro. Zool. Sci. 12: 499-502. [Full text]
Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4.
Conover, J.C., Erickson, J.T., Katz, D.M., Bianchi, L.M., Poueymirou, W.T., McClain, J., Pan, L., Helgren, M., Ip N.Y., Boland, P., Friedman, B., Weigand, S., Vejsada, R., Kato, A., DeChiara, T.M. and Yancopoulos, G.D. Nature 375: 235-238. [Abstract]
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
DeChiara, T.M., Vejsada, R., Pouyemirou, W.T., Acheson, A., Suri, C., Conover, J.C., McClain, J., Pan, L., Stahl, N., Ip N.Y., Kato, A., and Yancopoulos, G.D. Cell 83: 313-322. [Abstract] [Full text]
Cloning of the a component of the chick ciliary neurotrophic factor receptor: developmental expression and downregulation in denervated skeletal muscle
Ip F.C.F., Fu A.K.Y., Tsim K.W.K. and Ip N.Y. J. Neurochem. 65: 2393-2400. [Abstract]
1994
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
Overlapping and distinct actions of the neurotrophins, BDNF, NT-3 and NT-4/5, on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon
Hyman, C., Juhasz, M., Jackson, C., Wright, P., Ip N.Y., and Lindsay, R.M. J. Neurosci. 14: 335-347. [Full text]
Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve
Curtis, R., Scherer, S.S., Somogyi, R., Adryan, K.M., Ip N.Y., Zhu Y., Lindsay, R.M. and DiStefano, P.S. Neuron 12: 191-204. [Abstract]
Leukemia inhibitory factor and neurotrophins support overlapping populations of rat nodose sensory neurons in culture
Thaler, C., Suhr, L., Ip N.Y., and Katz, D. Developmental Biology 161: 338-344. [Abstract]
Neurotrophic factor receptors and their signal transduction capabilities in astrocytes
Rudge, J.S., Li, Y., Pasnikowski, E.M., Mattsson, K., Pan, L., Yancopoulos, G.D., Wiegand, S.J., Lindsay, R.M. and Ip N.Y. Eur. J. Neurosci. 6: 693-705. [Abstract]
The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor
Stahl, N., Boulton, T.G., Ip N.Y., Davis, S., and Yancopoulos, G.D. Brazilian J. Med. Biol. Res. 27: 297-301.
Expression of p140 trk in MAH cells lacking p75LNGFR is sufficient to permit NGF-induced differentiation to post-mitotic neurons
Verdi, J.M., Ip N.Y., Yancopoulos, G.D., and Anderson, D.J. Proc. Natl. Acad. Sci. USA 91: 3949-3953. [Full text]
CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons
Ip N.Y., Boulton, T.G., Li, Y., Verdi, J.M., Birren, S.J., Anderson, D.J. and Yancopoulos, G.D. Neuron 13: 443-455. [Abstract]
in situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]-NT-3
Altar, C.A., Siuciak, J.A., Wright, P., Lindsay, R.M., Ip N.Y. and Wiegand, W.J. Eur. J. Neurosci. 6: 1389-1405. [Abstract]
Neurotrophic factors collaborate to drive differentiation of neuronal progenitor cells
Ip N.Y. Neurosci. Lett. 45: 52.
1993
Cloning and analysis of neurotrophic factor receptors using function-based strategies
Glass, D.J., Gies, D.R., Stitt, T.N., Davis, S., Hantzopoulos, P., Ip N.Y., Goldfarb, M., and Yancopoulos, G.D. Cold Spring Harbor Symposia on Quantitative Biology 57: 53-62.
The neurotrophins BDNF, NT-3, and NT-4, but not NGF, up-regulate the cholinergic phenotypic of developing motor neurons
Wong V., Arriaga, R., Ip N.Y. and Lindsay, R.M. Eur. J. Neurosci. 5: 466-474. [Abstract]
Released form of CNTF receptor α component as a soluble mediator of CNTF responses
Davis, S., Aldrich, T.H., Ip N.Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., and Yancopoulos, G.D. Science 259: 1736-1739. [Abstract]
Injury-induced regulation of CNTF mRNA in the adult rat brain
Ip N.Y., Morse, J.K., Wiegand, S.J. and Rudge, J.S. Eur. J. Neurosci. 5: 25-33. [Abstract]
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion
Ibanez, C.F., Ernfors, P., Timmusk, T., Ip N.Y., Arenas, E., Yancopoulos, G.D., and Persson, H. Development 117: 1345-1353. [Full text]
Alternate forms of rat TrkC with different functional capabilities
Valenzuela, D.M., Maisonpierre, P.C., Glass, D.J., Rojas, E., Nunez, L., Kong, Y., Gies, D.R., Stitt, T.N., Ip N.Y. and Yancopoulos, G.D. Neuron 10: 963-974. [Abstract]
Crosslinking of CNTF and LIF to endogenous and reconstructed receptor complexes identifies LIF binding protein as a CNTF receptor component
Stahl, N., Davis, D., Wong, V., Taga, T., Tadamitsu, K., Ip N.Y. and Yancopoulos, G.D. J. Biol. Chem. 268: 7628-76. [Abstract] [Full text]
LIFR β and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
Davis, S., Aldrich, T., Stahl, N., Pan L., Taga, T., Kishimoto, K., Ip N.Y. and Yancopoulos, G.D. Science 260: 1805-1808. [Abstract]
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A.M., Ip N.Y. and Poo M. Nature 363: 350-353. [Abstract]
Cultured hippocampal neurons show responses to BDNF, NT-3 and NT-4 but not NGF
Ip N.Y., Li Y., Yancopoulos, G.D. and Lindsay, R.M. J. Neurosci. 13: 3394-3405. [Full text]
Ciliary neurotrophic factor maintains pluripotentiality of embryonic stem cells
Conover, J.C., Ip N.Y., Poueymirou, W.T., Bates, B., Goldfarb, M.P., DeChiara, T.M., and Yancopoulos, G.D. Development 119: 559-565. [Abstract] [Full text]
Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3
Sofroniew, M.V., Cooper, J.D., Svendsen, C.N., Crossman, P., Ip N.Y., Lindsay, R.M., Zafra, F., and Lindholm, D. J. Neurosci. 13: 5263-5276. [Full text]
1992
Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity
Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D. Proc. Natl. Acad. Sci. USA 89: 3060-3064. [Full text]
Expression of ciliary neurotrophic factor and the neurotrophins - Nerve growth factor, brain derived neurotrophic factor and neurotropin3- in cultured rat hippocampal astrocytes
Rudge, J.S., Alderson, R.F., Pasnikowski, E., McClain, J., Ip N.Y. and Lindsay, R.M. Eur. J. Neurosci. 4: 459-471. [Abstract]
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses
CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130
Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D. Cell 69: 1121-1132. [Abstract]
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip N.Y. Neuron 9: 295-305. [Abstract]
1991
Human and rat BDNF and NT-3: Gene structures, distributions and chromosomal localizations
Maisonpierre, P.C., Le Beau, M.M., Espinosa III, R., Ip N.Y., Belluscio, L., de la Monte, S.M., Squinto, S., Furth, M.E. and Yancopoulos, G.D. Genomics 10: 558-568. [Abstract]
Erks: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Boulton, T.G., Nye, S.H., Robbins, D.J., Ip N.Y., Radziejewska, E., Morgenbesser, S.D., DePinho, R.A., Panayotatos, N., Cobb, M.H., and Yancopoulos, G.D. Cell 65: 663-675. [Abstract]
The neurotrophin family of NGF-related neurotrophic factors
Lindsay, R.M., Alderson, R.F., Friedman, B., Hyman, C., Ip N.Y., Furth, M.E., Maisonpierre, P.C., Squinto, S.P. and Yancopoulos, G.D. Restorative Neurology and Neuroscience 2: 211-220. [Full text]
Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures
Ip N.Y., Li, Y., van de Stadt, I., Panayotatos, N., Alderson, R.F., and Lindsay, R.M. J. Neurosci. 11: 3124-3134. [Full text]
The neurotrophins and CNTF: Specificity of action towards PNS and CNS neurons
Ip N.Y., Maisonpierre, P., Alderson, R., Friedman, B., Furth, M.E., Panayotatos, N., Squinto, S., Yancopoulos, G.D. and Lindsay, R.M. J. Physiol., Paris 85: 123-130.
1990
DNA linkage analysis and studies of the androgen receptor gene in a large kindred with complete androgen insensitivity
Imperato-McGinley, J., Ip N.Y., Gautier, T., Neuweiler, J., Gruenspan, H., Liao, S., Chang, C., and Balazs, I. Am. J. of Med. Genet. 36: 104-108. [Abstract]
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
Maisonpierre, P.C., Belluscio, L., Squinto, S., Ip N.Y., Furth, M.E., Lindsay, R.M., and Yancopoulos, G.D. Science 247: 1446-1451. [Abstract]
Neurotrophic factors, their receptors, and the signal transduction pathways they activate
Yancopoulos, G.D., Maisonpierre, P.C., Ip N.Y., Aldrich, T.H., Belluscio, L., Boulton, T.G., Cobb, M.H., Squinto, S.P. and Furth, M.E. Cold Spring Harbor Symposia on Quantitative Biology 55: 371-379.
1989
Activation of ganglionic tyrosine hydroxylase by peptides of the glucagon-secretin family: Structure-function studies
Schwarzchild, M.A., Vale, W., Corigliano-Murphy, A.C., Pisano, J.J., Ip N.Y. and Zigmond, R.E. Neuroscience 31: 159-167. [Abstract]
Identification and Characterization of a hypervariable region [D18S27] on chromosome 18
Ip N.Y., van de Stadt, I., Loewy, Z., Leary, S., Grzeschik, K. and Balazs, I. Nuc. Acids. Res. 17: 8404. [Full text]
Discovery of a novel multilocus DNA polymorphism
Ip N.Y., Nicholas, L., Baum, H. and Balazs, I. Nuc. Acids. Res. 17: 4427. [Full text]
1985
Long-term regulation of tyrosine hydroxylase activity in the superior cervical ganglion in organ culture: Effects of nerve stimulation and dexamethasone
Ip N.Y. and Zigmond, R.E. Brain Research 338: 61-70. [Abstract]
Regulation of the concentration of cAMP and the activity of tyrosine hydroxylase in the rat superior cervical ganglion by three neuropeptides of the secretin family
Ip N.Y., Baldwin, C. and Zigmond, R.E. J. Neuroscience 5: 1947-1954. [Full text]
1984
Acute stimulation of ganglionic tyrosine hydroxylase activity by secretin, VIP and PHI
Ip N.Y., Baldwin, C. and Zigmond, R.E. Peptides 5: 309-312. [Abstract]
Substance P inhibits the acute stimulation of ganglionic tyrosine hydroxylase activity by a nicotinic agonist
Ip N.Y. and Zigmond, R.E. Neuroscience 13: 217-220. [Abstract]
Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event
Ip N.Y. and Zigmond, R.E. Nature 311: 472-474. [Abstract]
1983
Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms
Ip N.Y., Perlman, R.L. and Zigmond, R.E. Proc. Natl. Acad. Sci. USA 80: 2081-2085. [Full text]
1982
Both nicotinic and muscarinic agonists acutely increase tyrosine 3-m, onooxgenase activity in the superior cervical ganglion
Ip N.Y., Perlman, R.L. and Zigmond, R.E. J. Pharmacol. Exp. Ther. 223: 280-283. [Abstract] [Full text]
Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion
Ip N.Y., Ho, C.K. and Zigmond, R.E. Proc. Natl. Acad. Sci. USA 80: 2081-2085. [Full text]
1980
Characterization and regulation of receptors for epidermal growth factor in mouse calvaria
Shupnik, M.A., Ip N.Y. and Tashjian, A.H., Jr. Endocrinology 107: 1738-1746. [Abstract]
2024
Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification
Huan Zhong, Xiaopu Zhou, Hyebin Uhm, Yuanbing Jiang, Han Cao, Yu Chen, Tiffany T. W. Mak, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Y. Mok, Andrew Lung Tat Chan, Timothy C. Y. Kwok, Vincent C. T. Mok, Fanny C. F. Ip, John Hardy, Amy K. Y. Fu, Nancy Y. Ip
Alzheimers Dement. 2024 Feb 7. doi: 10.1002/alz.13691.
[Abstract] [Full text]
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.
Yuanbing Jiang, Hyebin Uhm, Fanny C. Ip, Li Ouyang, Ronnie M. N. Lo, Elaine Y. L. Cheng, Xiaoyun Cao, Clara M. C. Tan, Brian C. H. Law, Paula Ortiz-Romero, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Kin Y. Mok, John Hardy, Timothy C. Y. Kwok, Vincent C. T. Mok, Marc Suárez-Calvet, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip
Alzheimers Dement. 2024 Jan 6. doi: 10.1002/alz.13676. PMID: 38183344
[Abstract] [Full text]
2023
The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
Lau S.F., Wu W., Wong H.Y., Ouyang L., Qiao Y., Xu J., Lau H.Y.J., Wong C., Jiang Y., Holtzman D.M., Fu A.K.Y. and Ip N.Y.
Nature Aging 2023 Sep 21. doi: 10.1038/s43587-023-00491-1.
[Abstract] [Full text]
[ALZFORUM] Does Plaque ApoE Summon Microglia to Amyloid?
[Nature Review Neurology] ApoE attracts microglia to amyloid-β plaques
Deep learning-based polygenic risk analysis for Alzheimer's disease prediction
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen J., Ye T., Chen Y., Zhang Y., Ma S., Lo M.N.R., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Guo Q., Mok K.Y., Shoai M., Hardy J., Chen L., Fu A.K.Y. and Ip N.Y.
Commun Med (Lond) 2023; 3: 49. doi: 10.1038/s43856-023-00269-x
[Abstract] [Full text]
[The Croucher Foundation] Deep-learning AI could predict Alzheimer's risk
2022
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
Jiang Y., Zhou X., Wong H.Y., Ouyang L., Ip F.C.F., Chau M.N.V., Lau S.F., Wu W., Wong Y.K.D., Seo H., Fu W.Y., Lai C.H.N., Chen Y., Chen Y., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Mok C.Y.T., Shoai M., Lehallier B., Losada P.M., O’Brien E., Porter T., Laws S.M., Hardy J., Wyss-Coray T., Masters C.L., Fu A.K.Y. and Ip N.Y.
Nature Aging 2, 616–634 (2022). https://doi.org/10.1038/s43587-022-00241-9
[Abstract] [Full text]
[ALZFORUM] Receptor Decoy Raises Risk of Alzheimer's — But Only in Women
Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping
Qin Z., She Z., Chen C., Wu W., Lau J.K.Y., Ip N.Y., Qu J.Y.
Nat Biotechnol. 2022 Jun 13. doi: 10.1038/s41587-022-01343-w. PMID: 35697805
[Abstract] [Full text]
Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology
Park J.C., Barahona-Torres N., Jang S.Y., Mok K.Y., Kim H.J., Han S.H., Cho K.H., Zhou X., Fu A.K.Y., Ip N.Y., Seo J., Choi M., Jeong H., Hwang D., Lee D.Y., Byun M.S., Yi D., Han J.W., Mook-Jung I., Hardy J.
Adv Sci (Weinh). 2022 Jun 13;e2201212. doi: 10.1002/advs.202201212
[Abstract] [Full text]
Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk
Cao H., Zhou X., Chen Y., Ip F.C.F., Chen Y., Lai N.C.H., Lo R.M.N., Tong E.P.S., Mok V.C.T., Kwok T.C.Y.; Alzheimer’s Disease Neuroimaging Initiative, Fu A.K.Y., Ip N.Y.
J Alzheimers Dis. 2022;86(4):1861-1873. doi: 10.3233/JAD-215311. PMID: 35253752
[Abstract] [Full text]
Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong
Wong H.Y., Zhong H., Zhong M., Zhou X., Chan P.Y.C., Kwok T.C.Y., Mok K., Hardy J., Ip F.C.F., Fu A.K.Y., Ip N.Y.
J Alzheimers Dis. 2022 Apr 16. doi: 10.3233/JAD-215312. PMID: 35466936
[Abstract] [Full text]
2021
Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population
Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 2021 Dec;17 Suppl 3:e056625. doi: 10.1002/alz.056625. PMID: 35109110
[Abstract] [Full text]
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
Goertsen D., Flytzanis N.C., Goeden N., Chuapoco M.R., Cummins A., Chen Y., Fan Y., Zhang Q., Sharma J., Duan Y., Wang L., Feng G., Chen Y., Ip N.Y., Pickel J., Gradinaru V.
Nat Neurosci. 2021 Dec 9. doi: 10.1038/s41593-021-00969-4. PMID: 34887588
[Abstract] [Full text]
A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D
Wu M.Y., Wong A.Y.H., Leung J.K., Kam C., Wu K.L., Chan Y.S., Liu K., Ip N.Y. and Chen S.
Proc Natl Acad Sci U S A; 2021 Nov 9;118(45):e2106143118. doi: 10.1073/pnas.2106143118. PMID: 34740969
[Abstract] [Full text]
Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model
Fu W.Y., Hung K.W., Lau S.F., Butt B., Yuen V.W., Fu G., Chan I.C., Ip F.C.F., Fu A.K.Y. and Ip N.Y.
ACS Chem Neurosci. 2021 Nov 5. doi: 10.1021/acschemneuro.1c00600. PMID: 34738783
[Abstract] [Full text]
A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice
Ip F.C.F., Fu G., Yang F., Kang F., Sun P., Ling C.Y., Cheung K., Xie F., Hu Y., Fu L. and Ip N.Y.
Eur J Med Chem. 2021 Sep 13;226:113827. doi: 10.1016/j.ejmech.2021.113827. PMID: 34530383
[Abstract] [Full text]
Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Duan Y., Ye T., Qu Z., Chen Y., Miranda A., Zhou X., Lok K.C., Chen Y., Fu A.K.Y., Gradinaru V. and Ip N.Y.
Nat Biomed Eng. 2021 Jul 26. doi: 10.1038/s41551-021-00759-0.PMID: 34312508
[Abstract] [Full text]
IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry
Wang Y., Fu A.K.U. and Ip N.Y.
DNA Cell Biol. 2021 Jul 22. doi: 10.1089/dna.2021.0491.
[Abstract]
GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease
Xu P., Chang J.C., Zhou X., Wang W., Bamkole M., Wong E., Bettayeb K., Jiang L.L., Huang T., Luo W., Xu H., Nairn A.C., Flajolet M., Ip N.Y., Li Y.M., Greengard P.
J Exp Med. 2021 Aug 2;218(8):e20202446. doi: 10.1084/jem.20202446.
[Abstract] [Full text]
Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging
Jiang Y., Zhou X., Ip F.C., Chan P., Chen Y., Lai N.C.H., Cheung K., Lo R.M.N., Tong E.P.S., Wong B.W.Y., Chan A.L.T., Mok V.C.T., Kwok T.C.Y., Mok K.Y., Hardy J., Zetterberg H., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12369.
[Abstract] [Full text]
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
Lau S.F., Chen C., Fu W.Y., Qu J.Y., Cheung T.H., Fu A.K.Y. and Ip N.Y.
Cell Rep. 2020 Apr 21;31(3):107530. doi: 10.1016/j.celrep.2020.107530.
[Abstract] [Full text]
Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model
Lau J.K.Y., Tian M., Shen Y., Lau S.F., Fu W.Y., Fu A.K.Y. and Ip N.Y.
Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4.
[Abstract] [Full text]
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
Ye T., Duan Y., Tsang H.W.S., Chen Y., Cao H., Chen Y., Fu A.K.Y. and Ip N.Y.
Communications Biology 4, Article number: 195 (2021)
[Abstract] [Full text]
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
Lau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y.
STAR Protocols STAR Protoc. 2021 Jan 13;2(1):100265. doi: 10.1016/j.xpro.2020.100265. eCollection 2021 Mar 19.
[Abstract] [Full text]
Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus
Wang Y., Fu W.Y., Cheung K., Hung K.W., Chen C., Geng H., Yung W.H., Qu J.Y., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. January 5, 2021 118 (1) e2020810118; https://doi.org/10.1073/pnas.2020810118
[Abstract] [Full text]
2020
p39-associated Cdk5 activity regulates dendritic morphogenesis
Ouyang L., Chen Y., Wang Y, Chen Y., Fu A.K.Y., Fu W.Y. and Ip N.Y.
Sci. Rep. 10, Article number: 18746 (2020)
[Abstract] [Full text]
Adaptive optics two-photon endomicroscopy enables deep-brain imaging at synaptic resolution over large volumes
Qin Z., Chen C., He S., Wang Y., Tam K.F., Ip N.Y. and Qu J.Y.
Sci Adv. 2020 Sep 30;6(40):eabc6521. doi: 10.1126/sciadv.abc6521
[Abstract] [Full text]
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
Lau S.F., Cao H., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. 2020 Sep 28. www.pnas.org/cgi/doi/10.1073/pnas.2008762117
[Abstract] [Full text]
A pentacyclic triterpene from Ligustrum lucidum targets γ-secretase.
Luo W., Ip F.C.F., Fu G., Cheung K., Tian Y., Hu Y., Sinha A., Cheng E.Y.L., Wu X., Bustos V., Greengard P., Li Y.M., Sinha S.C., and Ip N.Y.
ACS Chem Neurosci. 2020 Aug 10. doi: 10.1021/acschemneuro.0c00389.
[Abstract] [Full text]
Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population
Zhou X., Chen Y., Ip F.C.F., Lai N.C.H., Li Y.Y.T., Jiang Y., Zhong H., Chen Y., Zhang Y., Ma S., Lo R.M.N., Cheung K., Tong E.P.S., Ko H., Shoai M., Mok K.Y., Hardy J., Mok V.C.T., Kwok T.C.Y., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement (Amst). 2020 Aug 5;12(1):e12074. doi: 10.1002/dad2.12074. eCollection 2020.
[Full text] [Full text]
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
Lau S.F., Chen C., Fu W.Y., Qu Y., Cheung T.H.T., Fu A.K.Y. and Ip N.Y.
BioWorld Science Editor's Choice [Abstract] [Full text]Cell Reports 2020 Apr 21; (31)107530. doi.org/10.1016/j.celrep.2020.107530
[Abstract] [Full text]
2019
Asymmetric Total Syntheses of Rhynchophylline and Isorhynchophylline.
Zhang Z., Zhang W., Kang F., Ip F.C.F., Ip N.Y. and Tong R.
J Org Chem. 2019 Aug 16. doi: 10.1021/acs.joc.9b01977.
[Abstract] [Full text]
Non-coding variability at the APOE locus contributes to the Alzheimer's risk
Zhou X., Chen Y., Mok K.Y., Kwok T.C.Y., Mok V.C.T., Guo Q., Ip F.C.F., Chen Y., Mullapudi N.; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P., Sullivan P.F., Hardy J., Fu A.K.Y., Li Y. and Ip N.Y.
Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.
[Abstract] [Full text]
α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis
Su Y., Lau S.F., Ip J.P.K., Cheung K., Cheung T.H.T. , Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. 2019 Jun 17. pii: 201903891. doi: 10.1073/pnas.1903891116.
[Abstract] [Full text]
Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect
Chen W.-W., Fu W.Y., Su Y., Fang W.-Q., Fu A.K.Y. and Ip N.Y.
Sci. Rep. 2019 Feb 4;9(1):1190. doi: 10.1038/s41598-018-38103-3.
[Abstract] [Full text]
2018
In Vivo near-infrared two-photon imaging of amyloid plaques in deep brain of Alzheimer’s Disease mouse model
Chen C., Liang Z., Zhou B., Li X., Lui C., Ip N.Y. and Qu J.
ACS Chem. Neurosci. DOI: 10.1021/acschemneuro.8b00306 Publication Date (Web): August 1, 2018
[Abstract] [Full text]
Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses
Ng Y.P., Yip T.F., J.S. Malik Peiris, Ip N.Y. and Lee M.Y. Suki
Journal of NeuroVirology 2018 Jul 9. doi: 10.1007/s13365-018-0659-8.
[Abstract]
Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs
Gu S., Fu W.Y., Fu A.K.Y., Tong E.P.S., Ip F.C.F., Huang X. and Ip N.Y.
Scientific Reports 2018 May 9;8(1):7377. doi: 10.1038/s41598-018-25790-1.
[Full text] [Full text]
Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex–nucleus accumbens pathway in mice
Cui Q., Li Q., Geng H., Chen L., Ip N.Y., Ke Y., and Yung W.H.
Proc. Natl. Acad. Sci. USA. 2018 May 22;115(21):E4890-E4899. doi: 10.1073/pnas.1717106115. Epub 2018 May 7.
[Full text] [Full text]
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
Zhou X., Chen Y., Mok K.Y., Zhao Q., Chen K., Chen Y., Hardy J., Li Y., Fu A.K.Y., Guo Q., Ip N.Y. and for the Alzheimer’s Disease Neuroimaging Initiative
Proc. Natl. Acad. Sci. USA. February 20, 2018. 115 (8) 1697-1706; published ahead of print February 5, 2018; https://doi.org/10.1073/pnas.1715554115.
[Full text] [Full text]
2017
A new iridoid glycoside and a new cinnamoyl glycoside from Scrophularia ningpoensis Hemsl
Zhang J., Ip F.C.F., Liang Y., Ip N.Y., Zhong B., Lai C.W., Xu S.
Nat Prod Res. 2017 Oct;31(20):2361-2368. doi: 10.1080/14786419.2017.1306704. Epub 2017 Mar 22.
[Abstract]
Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses
Ng Y.P., Yip T.F., J.S. Malik Peiris, Ip N.Y. and Lee M.Y. Suki
Journal of NeuroVirology 2018 Jul 9. doi: 10.1007/s13365-018-0659-8.
[Abstract]
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development
Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y.
Proc Natl Acad Sci USA. August 15, 2017. 114 (33) E6992-E7001; published ahead of print July 31, 2017. https://doi.org/10.1073/pnas.1708240114
[Full text] [Full text]
Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response
Ip F.C.F., Ng Y.P., Or C.T.T., Sun P., Fu G., Li Y.H.J., Ye W., Cheung T.H. and Ip N.Y.
PLoS One. 2017 Jul 31;12(7):e0182069. doi: 10.1371/journal.pone.0182069. eCollection 2017.
[Full text] [Full text]
Diarylheptanoids from Rhizomes of Alpinia officinarum inhibit aggregation of alpha-synuclein
Fu G., Zhang W., Du D., Ng Y.P., Ip F.C.F., Tong R. and Ip N.Y.
J Agric Food Chem. 2017 Jul 14. doi: 10.1021/acs.jafc.7b02021.
[Abstract] [Full text]
Two pairs of unusual melibiose and raffinose esters from Scrophularia ningpoensis
Zhang J., Liang Y., Ip F.C.F., Ip N.Y., Liu T., Zhong B. and Xu S.
J Asian Nat Prod Res. 2017 May 24:1-8. doi: 10.1080/10286020.2017.1329301.
A molecular switch regulating cell fate choice between muscle progenitor cells and brown adipocytes
An Y., Wang G., Diao Y., Long Y., Fu X., Weng M., Zhou L., Sun K., Cheung T.H., Ip N.Y., Sun H., Wang H. and Wu Z.
Dev Cell. 2017 May 22;41(4):382-391.e5. doi: 10.1016/j.devcel.2017.04.012.
[Abstract]
2016
Stimulation of the hippocampal POMC/MC4R circuit alleviates synaptic plasticity impairment in an Alzheimer's Disease model
Shen Y., Tian M., Zheng Y., Gong F., Fu A.K.Y. and Ip N.Y.
Cell Rep. 2016 Nov 8;17(7):1819-1831. doi: 10.1016/j.celrep.2016.10.043.
[Abstract] [Full text]
Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats
Ip F.C.F., Zhao Y., Chan K.W., Cheng E.Y., Tong E.P., Chandrashekar O., Fu G., Zhao Z. and Ip N.Y.
BMC Complement Altern Med. 2016 Nov 4;16(1):437 DOI 10.1186/s12906-016-1417-1
[Abstract] [Full text]
China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing
Poo M., Du J., Ip N.Y., Xiong Z., Xu P. and Tan T.
Neuron 2016 Nov 2;92(3):591-596. doi: 10.1016/j.neuron.2016.10.050
[Abstract] [Full text]
The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
Liang Z., Zhan Y., Shen Y., Wong C.C., Yates J.R. 3rd, Plattner F., Lai K.O. and Ip N.Y.
Nat. Commun. 7:13282, doi:10.1038/ncomms13282
[Abstract] [Full text]
Worldwide initiatives to advance brain research
Grillner S., Ip N.Y., Koch C., Koroshetz W., Okano H., Polachek M., Poo M. and Sejnowski T.
Nat. Neurosci. 19, 1118–1122 (2016) doi:10.1038/nn.4371
[Full text] [Full text]
Design and synthesis of dimeric securinine analogs with neuritogenic activities
Tang G., Liu X., Ma N., Huang X., Wu Z.L., Zhang W., Wang Y., Zhao B., Wang Z., Ip F.C.F., Ip N.Y., Ye W.C., Shi L. and Chen W.M.
ACS Chem Neurosci. July 28, 2016 doi: 10.1021/acschemneuro.6b00188
[Full text] [Full text]
STAT3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration
Zhu H., Xiao, F., Wang G., Wei X., Jiang L., Chen Y., Zhu L., Wang H., Diao Y., Wang H., Ip N.Y., Cheung T.H., and Wu Z.
Cell Reports 2016 Aug 10. pii: S2211-1247(16)30959-7. doi: 10.1016/j.celrep.2016.07.041
[Abstract] [Full text]
New lignans with neuroprotective activity from Adelostemma gracillimum
Zhang J., Guo S., Chan K.W., Tong E.P.S., Fu G., Mu Q., Ip F.C.F. and Ip N.Y.
Phytochem. Let. 19 (9): 1-5.
[Full text] [Full text]
Multicolor 4D fluorescence microscopy using Ultrathin Bessel Light Sheets
Zhao T., Lau S.C., Wang Y., Su Y., Wang H., Cheng A., Herrup K., Ip N.Y., Du S. and Loy M.M.
Science Report 2016 May 18;6:26159. doi: 10.1038/srep26159.
[Full text] [Full text]
IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline
Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y.
Proc Natl Acad Sci USA. May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016. https://doi.org/10.1073/pnas.1604032113
[Full text] [Full text] [F1000 Prime Recommended]
2015
Cdk5 regulates activity-dependent gene expression and dendrite development
Liang Z., Ye T., Zhou X., Lai, K.O., Fu A.K.Y. and Ip N.Y.
J. Neurosci. 11 November 2015, 35(45): 15127-15134; doi: 10.1523/JNEUROSCI.1443-15.2015
[Abstract] [Full text]
S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength
Zhang P., Fu W.Y., Fu A.K.Y. and Ip N.Y.
Nat. Commun. 6:8665. doi:10.1038/ncomms9665
[Abstract] [Full text] [F1000 Prime Recommended]
Axin regulates dendritic spine morphogenesis through Cdc42-dependent signaling
Chen Y., Liang Z., Fei E., Chen Y., Zhou X., Fang W., Fu W.Y., Fu A.K.Y. and Ip N.Y.
PLoS One 2015 Jul 23;10(7):e0133115. doi: 10.1371/journal.pone.0133115.
[Abstract] [Full text] [F1000 Prime Recommended]
Highly trans-selective arylation of Achmatowicz rearrangement products by reductive γ-Deoxygenation and Heck-Matsuda reaction: asymmetric total synthesis of (-)-musellarins A-C and their analogues
Li Z., Ip F.C.F., Ip N.Y. and Tong R.
Chemistry 2015 Jun 24. doi: 10.1002/chem.201501713.
[Abstract] [Full text]
Cdk5-dependent phosphorylation of p70 ribosomal S6 Kinase (S6K) is required for dendritic spine morphogenesis
Lai K.O., Liang Z., Fei E.,Huang H., and Ip N.Y.
J Biol Chem. 2015 Apr 22. doi: 10.1074/jbc.M114.627117
[Abstract] [Full text]
NRC-interacting factor directs neurite outgrowth in an activity-dependent manner
Zhao X.S., Fu W.Y., Hung K.W., Chien W.W.Y., Li Z., Fu A.K.Y. and Ip N.Y.
Neuroscience 2015 Mar 19;289:207-13. doi:10.1016/j.neuroscience.2014.12.041
[Abstract] [Full text]
Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection
Ip F.C.F., Fu W.Y., Cheng E.Y.L., Tong E.P.S., LOK K.C., Liang Y., Ye W.-C. and Ip N.Y.
Neuropsychopharmacology 2015 Feb 4. doi:10.1038/npp.2015.37
[Abstract] [Full text]
2014
Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Fang W.-Q., Chen W.-W., Jiang L., Liu K., Yung W.H., Fu A.K.Y. and Ip N.Y.
Cell Rep. 9(5):1635-43
[Abstract] [Full text]
p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1)
Zhao X., Fu W.Y., Chien W.W.Y., Li Z., Fu A.K.Y. and Ip N.Y.
PLoS One 2014 Oct 16;9(10):e110584. doi: 10.1371/journal.pone.0110584. eCollection 2014.
[Abstract] [Full text]
Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management
Ip F.C.F., Ng Y.P., An H.J., Dai Y., Pang H.H., Hu Y.Q., Chin A.C., Harley C.B., Wong Y.H. and Ip N.Y.
Neurosignals 2014;22(1):52-63. doi: 10.1159/000365290. Epub 2014 Jul 31.
[Abstract] [Full text]
Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex
Ye T., Ip J.P., Fu A.K.Y. and Ip N.Y.
Nat. Commun. 5:4826. doi: 10.1038/ncomms5826
[Abstract] [Full text]
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease
Fu A.K.Y., Hung K.W., Huang H., Gu S., Shen Y., Cheng E.Y., Ip F.C.F., Huang X, Fu W.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA 111(27):9959-64.
[Abstract] [Full text] [Highlighted in the commentary of PNAS]
Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition
Tang J., Ip J.P., Ye T., Ng Y.P., Yung W.H., Fu A.K.Y. and Ip N.Y.
J. Neurosci. 34(22):7425-7436.
[Abstract] [Full text] [This Week in The Journal]
Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton
Chen Y., Ip F.C.F., Shi L., Zhang Z., Tang H., Ng Y.P., Ye W.-C., Fu A.K.Y. and Ip N.Y.
J. Neurosci. 34(7):2413-2412.
[Abstract] [Full text]
2013
Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex
Fang W.-Q., Chen W.-W., Fu A.K.Y., and Ip N.Y.
Neuron 79:665-679. [Highlighted in F1000Prime]
[Abstract] [Full text] [Video Abstract] [F1000 Prime Recommended]
Melanocortin-4 receptor regulates hippocampal synaptic plasticity through PKA-dependent mechanism
Shen Y., Fu, W.Y., Cheng E.Y.L., Fu A.K.Y. and Ip N.Y.
J. Neurosci. 33(2):464-472.
[Abstract] [Full text]
2012
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory
Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y.
Nat. Neurosci. 15:1506-1515 [Highlighted in F1000Prime] [Highlighted in News and Views of Nat. Neurosci.]
[Abstract] [Full text] [F1000 Prime Recommended]
Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development
Chen Y., Fu W.Y., Ip J.P., Ye T., Fu A.K.Y., Chao M.V. and Ip N.Y.
J. Neurosci. 32:8263-9.
[Abstract] [Full text]
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2
Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y. and Ip N.Y.
Nat. Neurosci. 15:39-47. [Highlighted in F1000Prime]
[Abstract] [Full text] [F1000 Prime Recommended]
2011
Cdk5-mediated phosphorylation of axin directs axon formation during cerebral cortex development
Fang W.-Q., Ip J.P., Li R., Ng Y.P., Lin S-C, Chen Y., Fu A.K.Y. and Ip, N.Y.
J. Neurosci. 31(38):13613-24.
[Abstract] [Full text]
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y.
Nat. Neurosci. 14: 181-9. [Featured in News and Views of Nat. Neurosci.]
[Abstract] [Full text]
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H. and Ip N.Y.
Nat. Cell Biol. 13:568-579.
[Abstract] [Full text]
2010
S-nitrosylation of cyclin-dependent kinase 5 (Cdk5) regulates its kinase activity and dendrite growth during neuronal development
Zhang P., Yu P-C, Tsang A.H.K., Chen Y, Fu A.K.Y., Fu W.Y., Chung, K.K. and Ip N.Y.
J. Neurosci. 30(43):14366-14370.
[Abstract] [Full text]
Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease
Wan, J., Fu A.K.Y., Ip F.C.F., Ng H.K., Hugon J., Page G., Wang J.H., Lai K.O., Wu Z. and Ip N.Y.
J. Neurosci. 30(20): 6873-6881. [Highlighted in Alzheimer Research Forum]
[Abstract] [Full text]
Two Cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components
Ou C.Y., Poon V.Y., Maeder C.I., Watanabe S., Lehrman E.K., Fu A.K.Y., Park M., Fu W.Y., Jorgensen E.M., Ip N.Y., and Shen K.
Neuron 65: 204–216.
[Abstract] [Full text]
Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction
Shi L., Butt B., Ip F.C.F., Dai Y., Jiang L., Yung W.H., Greenberg, M.E., Fu A.K.Y. and Ip N.Y.
Neuron 65: 204–216.
[Abstract] [Full text] [F1000 Prime Recommended]
2009
Multiple Gi proteins participate in nerve growth factor-induced activation of c-jun N-terminal kinases in PC12 cells
Tso P.H., Morris C.J., Yung L.Y., Ip N.Y., and Wong Y.H.
Neurochemical Research 34: 1101-1112.
[Abstract] [Full text]
Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK
Hui K.P.Y., Lee S.M.Y., Cheung C.Y., Ng I.H.Y., Poon L.L.M., Guan Y., Ip N.Y., Lau A.S.Y., and Peiris, M.J.S.
J. Immunol. 182:1088-1098.
[Abstract] [Full text]
Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation
Ng Y.P., Wu Z., Wise, H., Tsim K.W.K., Wong Y.H., and Ip N.Y.
NeuroSignals 17: 111-120.
[Abstract] [Full text]
Identification of retinoic acid-regulated nuclear matrix-associated protein (RAMP) as a novel regulator of gastric cancer
Li J.J., Ng E.K., Ng Y.P., Wong C.Y.P., Yu J., Jin H.C., Cheng V.Y.Y., Go M.Y.Y., Cheung P.K.F., Man E.P.S., Ebert, M.P.A., Chan F.K.L. Sung J.J.Y., Ip N.Y., and Leung W.K.
British Journal of Cancer 101: 691-698
[Abstract] [Full text]
Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages
Lee S., Gardy, J., Cheung C.Y., Cheung T., Hui K., Ip N.Y., Guan Y., Hancock, R., and Peirs, J.S.
PLoS ONE 4(12): e8072
[Abstract] [Full text]
2008
Recent development in the search for effective antidepressants using traditional Chinese medicine
Pang T.H.H., Ip F.C.F. and Ip N.Y.
Central Nervous System Agents in Medicinal Chemistry 8:64-71.
[Abstract]
Hyper-induction of COX-2 mediated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1
Lee S.M.Y., Cheung C.Y., Nicholls, J.M., Hui K.P.Y., Leung C.Y.H., Uiprasertkul, M., Tipoe, G.L., Lau Y.L., Poon L.L.M., Ip N.Y., GuanY., and Peiris, M.J.S.
J. Infectious Disease 198: 525-535.
[Abstract] [Full text]
Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2
Cheung Z.H., Ke G. and Ip N.Y.
J. Neurosci 28: 4872-4877.
[Abstract] [Full text]
Endophilin B1 as a novel regulator of nerve growth factor/TrkA trafficking and neurite outgrowth
Wan J., Cheung A.Y., Fu W.Y., Wu C., Zhang M., Mobley, W.C., Cheung Z.H. and Ip N.Y.
J. Neurosci 28: 9002-9012.
[Abstract] [Full text]
Cdk5 activator p35 downregulates E-cadherin precursor independently of Cdk5
Lin S., Wang J., Ye Z., Ip N.Y., Lin S.C.
FEBS Lett. 582:1197-1202.
[Abstract] [Full text]
Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via Gi/o protein
Yung L.Y., Tso P.H., Wu E.H.T., Yu J.C.H., Ip N.Y. and Wong Y.H.
Cellular Signalling 20:1538-1544.
[Abstract] [Full text]
2007
Minor limonoids from Melia toosendan and their antibacterial activity
Zhang Q., Shi Y., Liu X.T., Liang J.Y., Ip N.Y., and Min Z.D.
Planta Medica 73: 1298-1303.
[Abstract] [Full text]
Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization
Nguyen C., Hosokawa T., Kuroiwa M., Ip N.Y., Nishi A., Hisanaga S.I., and Bibb, J.A.
Journal of Neurochemistry 103: 1582-1593.
[Abstract] [Full text]
一葉萩生物鹼類成分研究 (Alkaloids from Securinega suffruticosa)
Wang Y., Li Q., Ye W.C., Ip F.C.F., Ip N.Y., and Zhao S.X.
中草藥 (Chinese Traditional and Herbal Drugs) 38: 163-167.
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
Fu W.Y., Chen Y., Sahin, M., Zhao X.S., Shi L., Bikoff, J.B., Lai K.O., Yung W.H., Fu A.K.Y., Greenberg, M.E. and Ip N.Y.
Nat. Neurosci. 10: 67-76. [Highlighted in Alzheimer Research Forum and in J. Cell Biol. (2007). 176(1): 5]
[Abstract] [Full text]
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons
Cheung Z.H., Chin W.H., Chen Y., Ng Y.P. and Ip N.Y.
PLoS Biol. 5(4) : 867-865.
[Abstract] [Full text]
Expression of G protein β subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling
Lok K.C., Fu A.K.Y., Ip F.C.F., Wong Y.H. and Ip N.Y.
Neurosci. 146: 594-603.
[Abstract] [Full text]
Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization
Chan N., Hosokawa T., Ip N.Y., Hisanaga S., Bibb, J.A.
J. Neurochem. 103:1582-1593.
[Abstract] [Full text]
NRG induces membrane targeting of Gαz in muscle: implication in myogenesis
Lok K.C., Fu A.K.Y., Ip F.C.F., Wong Y.H., and Ip N.Y.
NeuroReport 18:1433-1436.
[Abstract]
α2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse
Shi L., Fu W.Y., Hung K.W., Porchetta, C., Hall, C., Fu A.K.Y., and Ip N.Y.
Proc. Natl. Acad. Sci. USA 104: 16347-16352.
[Abstract] [Full text]
Antibacterial diterpenoids from Sagittaria pygmaea
Liu X.T., Shi Y., Yu B., Williams, I.D., Sung H.H.Y., Zhang Q., Liang J.Y., Ip N.Y. and Min Z.D.
Planta Med. 73: 84-90.
[Abstract] [Full text]
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts
Sun L., Ma K., Wang H., Xiao F., Gao Y., Zhang W., Wang K., Gao X., Ip N.Y. and Wu Z.
J. Cell Biol. 179: 129-138.
[Abstract] [Full text]
2006
Chemical constituents of Securinega suffruticosa
Wang Y., Li Q., Ye W.C., Ip F.C.F., Ip N.Y. and Zhao S.X.
Chinese Journal of Natural Medicines 4: 260-263.
Pctaire1 phosphorylates N-Ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis
Liu Y., Cheng K., Ke G., Fu A.K.Y., and Ip N.Y.
J. Biol. Chem. 281: 9852-9858.
[Abstract] [Full text]
GABAB heterodimeric receptors promote Ca2+ influx via store-operated channels in transfected rat cortical neurons and transfected CHO cells
New, D.C., An H., Ip N.Y. and Wong Y.H.
Neuroscience 137: 1347-1358.
[Abstract] [Full text]
ent-Rosane and labdane diterpenoids from Sagittaria sagittifolia and their antibacterial activity against three oral pathogens
Liu X., Pan Q., Shi Y., Williams, I.D., Sung H.H., Zhang Q., Liang J., Ip N.Y. and Min Z.
J. Nat. Prod. 69: 255-260.
[Abstract] [Full text]
STAT3 as a downstream mediator of Trk signaling and functions
Ng Y.P., Cheung Z.H., and Ip N.Y.
J. Biol. Chem. 281: 15636-15644.
[Abstract] [Full text]
2005
Cytotoxic diterpenoids from the roots of Euphorbia ebracteolata
Shi H.M., Williams, I.D., Sung H.H., Zhu H.X., Ip N.Y. and Min Z.
Planta Medica 71: 349-54.
[Abstract] [Full text]
A DNA microarray for the authentication of toxic traditional Chinese medicinal plants
Carles, M., Cheung M.K.L., Moganti, S., Dong T.T.X., Tsim K.W., Ip N.Y. and Sucher, N.
Planta Medica 71: 580-584.
[Abstract] [Full text]
α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner
Luo S., Chen Y., Lai K.O., Arevalo, J.C., Froehner, S., Adams, M.E., Chao M. and Ip N.Y.
J. Cell Biol. 169: 813-824.
[Abstract] [Full text]
Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex
Gu Z., Jiang Q., Fu A.K.Y., Ip N.Y. and Yan Z.
J. Neurosci. 25: 4874-4984.
[Abstract] [Full text] [F1000 Prime Recommended]
Auto-inhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
Long J., Feng W., Wang R., Chan L.-N., Ip F.C.F., Xia J., Ip N.Y. and Zhang M.
Nat. Struct. Biol. 12: 722-728.
[Abstract] [Full text]
The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling
He W., Gong K., Smith, D.K. and Ip N.Y.
FEBS Letters 579: 4317-4323.
[Abstract] [Full text]
Agrin regulates growth cone turning of Xenopus spinal motoneurons
Xu X., Fu A.K.Y., Ip F.C.F., Wu C.-P., Duan, S., Poo M., Yuan, X. and Ip N.Y.
Development 132: 4309-4316.
[Abstract] [Full text]
Aberrant motor axon projection, AChR clustering and neurotransmission in cyclin-dependent kinase 5 null mice
Fu A.K.Y., Ip F.C.F., Fu W.Y., Cheng J., Wang J., Yung W.H. and Ip N.Y.
Proc. Natl. Acad. Sci. USA 102: 15224-15229.
[Abstract] [Full text]
SLAM-associated protein (SAP) as a potential negative regulator in Trk signaling
Lo K.Y., Chin W.H., Ng Y.P., Cheng W., Cheung Z.H. and Ip N.Y.
J. Biol. Chem. 280: 41744-41752.
[Abstract] [Full text]
2004
Melia toosendan regulates PC12 cell differentiation via the activation of a PKA-dependent ERK signaling pathway
Yu J.C.H., Min Z. and Ip N.Y.
NeuroSignals 13: 248-257.
[Abstract] [Full text]
Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay
Pan Q., Ip F.C.F., Ip N.Y., Zhu H. and Min Z.
J. Nat. Prod. 67: 1548-1551.
[Abstract] [Full text]
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription
Li Z., David, G., Hung K.W., DePinho, R.A., Fu A.K.Y. and Ip, N.Y.
J. Biol. Chem. 279: 54438-54444.
[Abstract] [Full text]
Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression
Lai K.O., Chen Y., Po H.-M., Lok K.C., Gong K. and Ip N.Y.
J. Biol. Chem. 279: 13383-13392.
[Abstract] [Full text]
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
Fu A.K.Y., Fu W.Y., Ng A.K.Y., Chien W.W.Y., Ng Y.P., Wang J. and Ip N.Y.
Proc. Natl. Acad. Sci. USA 101: 6728-6733.
[Abstract] [Full text]
2003
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Ng Y.P., He W., and Ip N.Y.
J. Biol. Chem. 278: 38731-38739.
[Abstract] [Full text]
Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free association among components of the CNTF receptor complex
Man, D., He W., Sze K.H., Gong K., Smith, D.K., Zhu G., and Ip N.Y.
J. Biol. Chem. 278: 23285-23294.
[Abstract] [Full text]
Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation
Xu Z., Lai K.O., Zhou H.M., Lin S.C. and Ip N.Y.
J. Biol. Chem. 278: 24767-24775.
[Abstract] [Full text]
2002
Induction of Cdk5 activity in rat skeletal muscle after nerve injurys
Fu W.Y., Fu A.K.Y., Lok K.C., Ip F.C.F. and Ip N.Y.
NeuroReport 13: 243-247.
[Abstract]
Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro
He W., Gong K., Zhu G., Smith, D.K. and Ip N.Y.
FEBS Letters 514: 214-218.
[Abstract] [Full text]
Expression of Cdk5 and its activators in NT2 cells during neuronal differentiation
Fu W.Y., Wang J.H. and Ip N.Y.
J. Neurochem. 81: 646-654.
[Abstract] [Full text]
Pctaire-1 interacts with p35 and is a novel substrate for Cdk5
Cheng K., Li Z., Fu W.Y., Wang J.H., Fu A.K.Y. and Ip N.Y.
J. Biol. Chem. 277: 31988-31993.
[Abstract] [Full text]
Genotyping on a complementary metal oxide semiconductor silicon PCR chip with integrated DNA microarray
Trau, D., Lenigk, R., Lao A.I.K., Lee T.M.H., Hsing I., Ip N.Y., Carles, M.C. and Sucher, N.
Analytical Chem. 74: 3168-3173.
[Abstract]
2001
A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine
Miller-Martini, D.M., Chan R.Y.K., Ip N.Y., Sheu S.J., and Wong Y.H.
Phytotherapy Research 15: 487-492.
[Abstract] [Full text]
The expression profiles of neurotrophins and their receptors in rat and chicken tissues during development
Ip F.C.F., Cheung J. and Ip N.Y.
Neurosci. Lett. 301: 107-110.
[Abstract] [Full text]
Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction
Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H. and Ip N.Y.
Nat. Neurosci. 4: 374-381.
[Abstract] [Full text]
Cloning and expression of a novel nuclear matrix associated protein that is regulated during the retinoic acid induced neuronal differentiation
Cheung W.M.W., Chu A.H., Chu P.W.K. and Ip N.Y.
J. Biol. Chem. 276: 17083-17091.
[Abstract] [Full text]
Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction
Lai K.O., Ip F.C.F., Cheung J., Fu A.K.Y. and Ip N.Y.
Mol. Cell. Neurosci. 17: 1034-1047.
[Abstract] [Full text]
Surface characterization of a silicon-based DNA microarray
Lenigk, R., Carles, M., Ip N.Y. and Sucher, N.J.
Langmuir 17: 2497-2501.
[Abstract]
Expression of P2Y1 nucleotide receptors in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptors
Choi R.C.Y., Man M.L.S., Ling K., Ip N.Y., Simon, J., Barnard, E.A. and Tsim K.W.K.
J. Neurosci. 21: 9224-9234.
[Abstract] [Full text]
Overexpression of muscle specific kinase increases the transcription and aggregation of acetylcholine receptors in Xenopus embryos
Fu A.K.Y., Cheung J., Xie P., Smith F.D. and Ip N.Y.
Mol. Brain Res. 96: 21-29.
[Abstract] [Full text]
Complete 1H, 15N and 13C assignments of the carboxylterminal domain of the ciliary neurotrophic factor receptor (CNTFR)
Man, D., Xia Y., Sze K.H., Smith D., He W., Ip N.Y. and Zhu G.
J. Biomolecular NMR 22: 95-96.
[Abstract]
2000
Synergistic effects of muscarinic agonists and secretin or vasoactive intestinal peptide on the regulation of tyrosine hydroxylase activity in sympathetic neurons
Ip N.Y. and Zigmond, R.E.
J. Neurobiol 42: 14-21.
[Abstract] [Full text]
Induction of TrkA expression by differentiation inducers in human myeloid leukemia KG-1 cells
Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
Leukemia & Lymphoma 36: 595-601.
[Abstract]
IL-6 enhanced the retinoic acid-induced differentiation of human acute promyelocytic leukemia cells
Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
Cancer Lett 148: 207-213.
[Abstract] [Full text]
Nerve growth factor potentiated the sodium butyrate- and PMA- induced megakaryocytic differentiation of K562 leukemia cells
Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
Leukemia Res 24: 751-759.
[Abstract] [Full text]
Developmental and tissue-specific expression of DEAD box protein p72
Ip F.C.F., Chung S.S.K., Fu W.Y., and Ip N.Y.
NeuroReport 11: 457-462.
[Abstract]
Precise temperature control of microfluidic chamber for gas and liquid phase reactions
Lao A.I.K., Lee T.M.H., Hsing I. and Ip N.Y.
Sensors and Actuators 84: 11-17.
[Abstract]
Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes following injury
Tang H., Fu W.Y. and Ip N.Y.
Neurosci. Lett. 285: 143-146.
[Abstract] [Full text]
Expression of retinoid receptors during the retinoic acid induced neuronal differentiation of a human embryonal carcinoma cell line
Cheung W.M.W., Chu P.W.K., Lung C.H. and Ip N.Y.
J. Neurochem. 75: 34-40.
[Abstract] [Full text]
Identification and characterization of differentially expressed genes in denervated muscle
Tang H., Cheung W.M.W., Ip F.C.F. and Ip N.Y.
Mol. Cell. Neurosci. 16: 127-140.
[Abstract] [Full text]
Ganoderma extract activates MAP kinase and induces the neuronal differentiation of rat pheochromocytoma PC12 cells
Cheung W.M.W., Hui W.S., Chu P.W.K., Chiu S.W. and Ip N.Y.
FEBS Letters 486: 291-296.
[Abstract] [Full text]
A J-multiplied HMQC (MJ-HMQC) experiment for measuring (3) J (HNA alpha) coupling constants
Xia Y.L., Kong X.M., Ip N.Y., and Zhu G.
J. Magnetic Resonance 146: 228-231.
[Abstract]
1999
Xenopus muscle specific kinase: molecular cloning and prominent expression in neural tissues during early embryonic development
Fu A.K.Y., Smith, F.D., Zhou H., Chu A.H., Tsim K.W.K., Peng H.B. and Ip N.Y.
Eur. J. Neurosci. 11: 373-382.
[Abstract] [Full text]
A cysteine-rich form of Xenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes
Yang J.F., Zhou H., Choi R.C.Y., Ip N.Y., Peng H.B. and Tsim K.W.K.
Mol. Cell. Neurosci. 13: 415-429.
[Abstract] [Full text]
Production of human CNS neurons from embryonal carcinoma cells using a cell aggregation method
Cheung W.M.W., Fu W.Y., Hui W.S. and Ip N.Y.
Biotechniques 26: 946-954.
Identification of genes induced by neuregulin in cultured myotubes
Fu A.K.Y., Cheung W.M.W., Ip F.C.F. and Ip N.Y.
Mol. Cell Neurosci. 14: 241-253.
[Abstract] [Full text]
Identification and characterization of splice variants of ephrin-A3 and ephrin-A5
Lai K.O., Ip F.C.F. and Ip N.Y.
FEBS Lett. 458: 265-269.
[Abstract] [Full text]
Induction of gp130 and LIF by differentiation inducers in human myeloid leukemia K562 cells
Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
Leukemia Res. 23: 1113-1119.
[Abstract] [Full text]
1998
Cloning and expression of a novel neurotrophin, NT-7, from carp
Lai K.O., Fu W.Y., Ip F.C.F. and Ip N.Y.
Mol. Cell. Neurosci. 11: 64-76.
[Abstract] [Full text]
Induction of NG108-15 cells differentiation by human bone marrow stromal cells
Ho S.H., So L.H., Lai K.O., Ip N.Y. and Leung M.F.
NeuroReport 9: 1365-1369.
[Abstract]
Cloning of cDNAs encoding Xenopus neuregulin: Expression in myotomal muscle during embryo development
Yang J.F., Zhou H., Pun S., Ip N.Y., Peng B. and Tsim K.W.K.
Mol Brain Res. 58: 59-73.
[Abstract]
Expression of BDNF and TrkB with age and age-related memory deficits
Croll, S.D., Ip N.Y., Lindsay, R.M. and Wiegand, S.J.
Brain Research 812: 200-208.
[Abstract] [Full text]
1997
Trauma-induced striatal CNTF and BDNF mRNA in hemiparkinsonian rats
Plunkett, R.J., Ip N.Y., Asada H., Friedman, B., Pan, L., Kaseloo, P.A. and Parfitt, M.M.
NeuroReport 8: 507-511.
[Abstract]
The EGF-like domain of chick acetylcholine receptor-inducing activity (ARIA) contains its full biological activity
Yang J.F., Ng Y.P., Pun S., Ip N.Y. and Tsim K.W.K.
FEBS Letters 403: 163-167.
[Abstract] [Full text]
Identification of candidate genes induced by retinoic acid in embryonal carcinoma cells
Cheung W.M.W., Chu A.H. and Ip N.Y.
J. Neurochem. 68: 1882-1888.
[Abstract] [Full text]
Induction of TrkA receptor by retinoic acid in leukemia cell lines
Xie P., Cheung W.M.W., Ip F.C.F., Ip N.Y. and Leung, M.F.
NeuroReport 8: 1067-1070.
[Abstract]
Chick muscle expresses various ARIA isoforms: Regulation during development, denervation and regeneration
Ng Y.P., Pun S., Ip F.C.F., Ip N.Y. and Tsim K.W.K.
Mol. Cell. Neurosci. 9: 132-143.
[Abstract] [Full text]
Agrin-deficient myotube retains its AChR aggregation ability when challenged with agrin
Pun S., Ng Y.P., Yan, J.F., Ip N.Y. and Tsim K.W.K.
J. Neurochem 69: 2555-2563.
[Abstract] [Full text]
Muscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures
Fu A.K.Y., Ip F.C.F., Lai K.O., Tsim K.W.K. and Ip N.Y.
NeuroReport 8: 3895-3900.
[Abstract]
1996
Induction of trk receptors by retinoic acid in a human embryonal carcinoma cell line
Cheung W.M.W., Chu A.H., Leung M.F. and Ip N.Y.
NeuroReport 7: 1204-1208.
[Abstract]
Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury
Ip F.C.F., Fu A.K.Y., Tsim K.W.K. and Ip N.Y.
J. Neurochem. 67: 1607-1612.
[Abstract] [Full text]
Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras
Lai K.O., Glass, D.J., Yancopoulos, G.D. and Ip N.Y.
J. Neurosci. Res. 46: 618-629.
[Abstract] [Full text]
1995
Binding characteristics of ciliary neurotrophic factor to sympathetic neurons and neuronal cell lines
Wong V., Pearsall, D., Arriaga R., Ip N.Y., Stahl N., and Lindsay, R.M.
J. Biol. Chem. 270: 313-318.
[Abstract] [Full text]
Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor
Valenzuela, D.M., Rojas E., Le Beau, M.M., Espinosa III., R., Brannan, C.I., McClain, J., Masiakowski, P., Ip N.Y., Copeland, N.G., Jenkins, N.A., and Yancopoulos, G.D.
J. Biol. Chem. 270: 313-318.
[Abstract] [Full text]
Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum
Asada H., Ip N.Y., Pan, L., Razack, N., Parfitt, M.M. and Plunkett, R.J.
J. Neurosci. Res. 40: 22-30.
[Abstract] [Full text]
Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family
Valenzuela, D.M., Rojas, E., Griffiths, J.A., Compton, D.L., Gisser, M., Ip N.Y., Goldfarb, M. and Yancopoulos, G.D.
Oncogene 10: 1573-1580.
Identification of mammalian noggin and its expression in the adult nervous syste
Valenzuela, D.M., Economides, A.N., Rojas, E., Lamb, T.M., Nunes, L., Jones, P., Ip N.Y., Espinosa, III, R., Brannan, C.I., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Le Beau, M.M., Harland, R.M. and Yancopoulos, G.D.
J. Neurosci. 15: 6077-6084.
[Full text]
Neurotrophin-3 augments steroid secretion by hamster ovarian follicles
Waraksa, J.A., Lindsay, R.M., Ip N.Y. and Hutz, R.J.
in vitro. Zool. Sci. 12: 499-502.
[Full text]
Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4.
Conover, J.C., Erickson, J.T., Katz, D.M., Bianchi, L.M., Poueymirou, W.T., McClain, J., Pan, L., Helgren, M., Ip N.Y., Boland, P., Friedman, B., Weigand, S., Vejsada, R., Kato, A., DeChiara, T.M. and Yancopoulos, G.D.
Nature 375: 235-238.
[Abstract]
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
DeChiara, T.M., Vejsada, R., Pouyemirou, W.T., Acheson, A., Suri, C., Conover, J.C., McClain, J., Pan, L., Stahl, N., Ip N.Y., Kato, A., and Yancopoulos, G.D.
Cell 83: 313-322.
[Abstract] [Full text]
Cloning of the a component of the chick ciliary neurotrophic factor receptor: developmental expression and downregulation in denervated skeletal muscle
Ip F.C.F., Fu A.K.Y., Tsim K.W.K. and Ip N.Y.
J. Neurochem. 65: 2393-2400.
[Abstract]
1994
Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
Stahl, N., Boulton, T.G., Farruggella, T., Ip N.Y., Davis, S., Witthuhn, B., Quelle, F.W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J.N. and Yancopoulos, G.D.
Science 263: 92-95.
[Abstract]
Overlapping and distinct actions of the neurotrophins, BDNF, NT-3 and NT-4/5, on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon
Hyman, C., Juhasz, M., Jackson, C., Wright, P., Ip N.Y., and Lindsay, R.M.
J. Neurosci. 14: 335-347.
[Full text]
Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve
Curtis, R., Scherer, S.S., Somogyi, R., Adryan, K.M., Ip N.Y., Zhu Y., Lindsay, R.M. and DiStefano, P.S.
Neuron 12: 191-204.
[Abstract]
Leukemia inhibitory factor and neurotrophins support overlapping populations of rat nodose sensory neurons in culture
Thaler, C., Suhr, L., Ip N.Y., and Katz, D.
Developmental Biology 161: 338-344.
[Abstract]
Neurotrophic factor receptors and their signal transduction capabilities in astrocytes
Rudge, J.S., Li, Y., Pasnikowski, E.M., Mattsson, K., Pan, L., Yancopoulos, G.D., Wiegand, S.J., Lindsay, R.M. and Ip N.Y.
Eur. J. Neurosci. 6: 693-705.
[Abstract]
The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor
Stahl, N., Boulton, T.G., Ip N.Y., Davis, S., and Yancopoulos, G.D.
Brazilian J. Med. Biol. Res. 27: 297-301.
Expression of p140 trk in MAH cells lacking p75LNGFR is sufficient to permit NGF-induced differentiation to post-mitotic neurons
Verdi, J.M., Ip N.Y., Yancopoulos, G.D., and Anderson, D.J.
Proc. Natl. Acad. Sci. USA 91: 3949-3953.
[Full text]
CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons
Ip N.Y., Boulton, T.G., Li, Y., Verdi, J.M., Birren, S.J., Anderson, D.J. and Yancopoulos, G.D.
Neuron 13: 443-455.
[Abstract]
in situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]-NT-3
Altar, C.A., Siuciak, J.A., Wright, P., Lindsay, R.M., Ip N.Y. and Wiegand, W.J.
Eur. J. Neurosci. 6: 1389-1405.
[Abstract]
Neurotrophic factors collaborate to drive differentiation of neuronal progenitor cells
Ip N.Y.
Neurosci. Lett. 45: 52.
1993
Cloning and analysis of neurotrophic factor receptors using function-based strategies
Glass, D.J., Gies, D.R., Stitt, T.N., Davis, S., Hantzopoulos, P., Ip N.Y., Goldfarb, M., and Yancopoulos, G.D.
Cold Spring Harbor Symposia on Quantitative Biology 57: 53-62.
The neurotrophins BDNF, NT-3, and NT-4, but not NGF, up-regulate the cholinergic phenotypic of developing motor neurons
Wong V., Arriaga, R., Ip N.Y. and Lindsay, R.M.
Eur. J. Neurosci. 5: 466-474.
[Abstract]
Released form of CNTF receptor α component as a soluble mediator of CNTF responses
Davis, S., Aldrich, T.H., Ip N.Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., and Yancopoulos, G.D.
Science 259: 1736-1739.
[Abstract]
Injury-induced regulation of CNTF mRNA in the adult rat brain
Ip N.Y., Morse, J.K., Wiegand, S.J. and Rudge, J.S.
Eur. J. Neurosci. 5: 25-33.
[Abstract]
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
Ip N.Y., McClain, J., Barrezueta, N., Aldrich, T.H., Pan, L., Li, Y., Wiegand, S.J., Friedman, B., Davis, S., and Yancopoulos, G.D.
Neuron 10: 89-102.
[Abstract]
Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion
Ibanez, C.F., Ernfors, P., Timmusk, T., Ip N.Y., Arenas, E., Yancopoulos, G.D., and Persson, H.
Development 117: 1345-1353.
[Full text]
Alternate forms of rat TrkC with different functional capabilities
Valenzuela, D.M., Maisonpierre, P.C., Glass, D.J., Rojas, E., Nunez, L., Kong, Y., Gies, D.R., Stitt, T.N., Ip N.Y. and Yancopoulos, G.D.
Neuron 10: 963-974.
[Abstract]
Crosslinking of CNTF and LIF to endogenous and reconstructed receptor complexes identifies LIF binding protein as a CNTF receptor component
Stahl, N., Davis, D., Wong, V., Taga, T., Tadamitsu, K., Ip N.Y. and Yancopoulos, G.D.
J. Biol. Chem. 268: 7628-76.
[Abstract] [Full text]
LIFR β and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
Davis, S., Aldrich, T., Stahl, N., Pan L., Taga, T., Kishimoto, K., Ip N.Y. and Yancopoulos, G.D.
Science 260: 1805-1808.
[Abstract]
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A.M., Ip N.Y. and Poo M.
Nature 363: 350-353.
[Abstract]
Cultured hippocampal neurons show responses to BDNF, NT-3 and NT-4 but not NGF
Ip N.Y., Li Y., Yancopoulos, G.D. and Lindsay, R.M.
J. Neurosci. 13: 3394-3405.
[Full text]
Ciliary neurotrophic factor maintains pluripotentiality of embryonic stem cells
Conover, J.C., Ip N.Y., Poueymirou, W.T., Bates, B., Goldfarb, M.P., DeChiara, T.M., and Yancopoulos, G.D.
Development 119: 559-565.
[Abstract] [Full text]
Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3
Sofroniew, M.V., Cooper, J.D., Svendsen, C.N., Crossman, P., Ip N.Y., Lindsay, R.M., Zafra, F., and Lindholm, D.
J. Neurosci. 13: 5263-5276.
[Full text]
1992
Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity
Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D.
Proc. Natl. Acad. Sci. USA 89: 3060-3064.
[Full text]
Expression of ciliary neurotrophic factor and the neurotrophins - Nerve growth factor, brain derived neurotrophic factor and neurotropin3- in cultured rat hippocampal astrocytes
Rudge, J.S., Alderson, R.F., Pasnikowski, E., McClain, J., Ip N.Y. and Lindsay, R.M.
Eur. J. Neurosci. 4: 459-471.
[Abstract]
K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses
Nye, S.H., Squinto S.P., Glass, D.J., Stitt, T.N., Hantzopoulos, P., Macchi, M.J., Lindsay, N.S., Ip N.Y. and Yancopoulos, G.D.
Mol. Biol. Cell 3: 677-686.
[Abstract] [Full text]
CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130
Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D.
Cell 69: 1121-1132.
[Abstract]
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip N.Y.
Neuron 9: 295-305.
[Abstract]
1991
Human and rat BDNF and NT-3: Gene structures, distributions and chromosomal localizations
Maisonpierre, P.C., Le Beau, M.M., Espinosa III, R., Ip N.Y., Belluscio, L., de la Monte, S.M., Squinto, S., Furth, M.E. and Yancopoulos, G.D.
Genomics 10: 558-568.
[Abstract]
Erks: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Boulton, T.G., Nye, S.H., Robbins, D.J., Ip N.Y., Radziejewska, E., Morgenbesser, S.D., DePinho, R.A., Panayotatos, N., Cobb, M.H., and Yancopoulos, G.D.
Cell 65: 663-675.
[Abstract]
The neurotrophin family of NGF-related neurotrophic factors
Lindsay, R.M., Alderson, R.F., Friedman, B., Hyman, C., Ip N.Y., Furth, M.E., Maisonpierre, P.C., Squinto, S.P. and Yancopoulos, G.D.
Restorative Neurology and Neuroscience 2: 211-220.
[Full text]
Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures
Ip N.Y., Li, Y., van de Stadt, I., Panayotatos, N., Alderson, R.F., and Lindsay, R.M.
J. Neurosci. 11: 3124-3134.
[Full text]
The neurotrophins and CNTF: Specificity of action towards PNS and CNS neurons
Ip N.Y., Maisonpierre, P., Alderson, R., Friedman, B., Furth, M.E., Panayotatos, N., Squinto, S., Yancopoulos, G.D. and Lindsay, R.M.
J. Physiol., Paris 85: 123-130.
1990
DNA linkage analysis and studies of the androgen receptor gene in a large kindred with complete androgen insensitivity
Imperato-McGinley, J., Ip N.Y., Gautier, T., Neuweiler, J., Gruenspan, H., Liao, S., Chang, C., and Balazs, I.
Am. J. of Med. Genet. 36: 104-108.
[Abstract]
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
Maisonpierre, P.C., Belluscio, L., Squinto, S., Ip N.Y., Furth, M.E., Lindsay, R.M., and Yancopoulos, G.D.
Science 247: 1446-1451.
[Abstract]
Neurotrophic factors, their receptors, and the signal transduction pathways they activate
Yancopoulos, G.D., Maisonpierre, P.C., Ip N.Y., Aldrich, T.H., Belluscio, L., Boulton, T.G., Cobb, M.H., Squinto, S.P. and Furth, M.E.
Cold Spring Harbor Symposia on Quantitative Biology 55: 371-379.
1989
Activation of ganglionic tyrosine hydroxylase by peptides of the glucagon-secretin family: Structure-function studies
Schwarzchild, M.A., Vale, W., Corigliano-Murphy, A.C., Pisano, J.J., Ip N.Y. and Zigmond, R.E.
Neuroscience 31: 159-167.
[Abstract]
Identification and Characterization of a hypervariable region [D18S27] on chromosome 18
Ip N.Y., van de Stadt, I., Loewy, Z., Leary, S., Grzeschik, K. and Balazs, I.
Nuc. Acids. Res. 17: 8404.
[Full text]
Discovery of a novel multilocus DNA polymorphism
Ip N.Y., Nicholas, L., Baum, H. and Balazs, I.
Nuc. Acids. Res. 17: 4427.
[Full text]
1985
Long-term regulation of tyrosine hydroxylase activity in the superior cervical ganglion in organ culture: Effects of nerve stimulation and dexamethasone
Ip N.Y. and Zigmond, R.E.
Brain Research 338: 61-70.
[Abstract]
Regulation of the concentration of cAMP and the activity of tyrosine hydroxylase in the rat superior cervical ganglion by three neuropeptides of the secretin family
Ip N.Y., Baldwin, C. and Zigmond, R.E.
J. Neuroscience 5: 1947-1954.
[Full text]
1984
Acute stimulation of ganglionic tyrosine hydroxylase activity by secretin, VIP and PHI
Ip N.Y., Baldwin, C. and Zigmond, R.E.
Peptides 5: 309-312.
[Abstract]
Substance P inhibits the acute stimulation of ganglionic tyrosine hydroxylase activity by a nicotinic agonist
Ip N.Y. and Zigmond, R.E.
Neuroscience 13: 217-220.
[Abstract]
Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event
Ip N.Y. and Zigmond, R.E.
Nature 311: 472-474.
[Abstract]
1983
Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms
Ip N.Y., Perlman, R.L. and Zigmond, R.E.
Proc. Natl. Acad. Sci. USA 80: 2081-2085.
[Full text]
1982
Both nicotinic and muscarinic agonists acutely increase tyrosine 3-m, onooxgenase activity in the superior cervical ganglion
Ip N.Y., Perlman, R.L. and Zigmond, R.E.
J. Pharmacol. Exp. Ther. 223: 280-283.
[Abstract] [Full text]
Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion
Ip N.Y., Ho, C.K. and Zigmond, R.E.
Proc. Natl. Acad. Sci. USA 80: 2081-2085.
[Full text]
1980
Characterization and regulation of receptors for epidermal growth factor in mouse calvaria
Shupnik, M.A., Ip N.Y. and Tashjian, A.H., Jr.
Endocrinology 107: 1738-1746.
[Abstract]