Zhou X., Chen Y., Mok K.Y., Zhao Q., Chen K., Chen Y., Hardy J., Li Y., Fu A.K.Y., Guo Q., Ip N.Y. and for the Alzheimer’s Disease Neuroimaging Initiative (2018)
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis.
Proc Natl Acad Sci U S A. February 20, 2018. 115 (8) 1697-1706; published ahead of print February 5, 2018. https://doi.org/10.1073/pnas.1715554115
[Abstract] [Full text]
Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y. (2017)
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
Proc Natl Acad Sci U S A. August 15, 2017. 114 (33) E6992-E7001; published ahead of print July 31, 2017. https://doi.org/10.1073/pnas.1708240114
[Abstract] [Full text]
Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y. (2016)
IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline
Proc. Natl. Acad. Sci. USA May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016. https://doi.org/10.1073/pnas.1604032113
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Zhang P., Fu W.Y., Fu A.K.Y.,Ip N.Y. (2015)
S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength
Nat. Commun. 2015 Oct 27;6:8665. doi: 10.1038/ncomms9665. [Highlighted in F1000Prime]
[Full text][Full text]
Fang W.-Q., Chen W.W., Jiang L., Liu K., Yung W.H., Fu A.K.Y., Ip N.Y. (2014)
Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice.
Cell Rep. 9(5):1635-43
[Abstract][Full text]
Ye T., Ip J.P., Fu A.K.Y., Ip N.Y. (2014)
Cdk5-mediated phosphorylation of ​RapGEF2 controls neuronal migration in the developing cerebral cortex.
Nat. Commun., 5:4826. doi: 10.1038/ncomms5826
[Abstract] [Full text]
Fu A.K.Y., Hung K.W., Huang H., Gu S., Shen Y., Cheng E.Y., Ip F.C.F., Huang X, Fu W.Y., Ip N.Y. (2014)
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.
Proc. Natl. Acad. Sci. USA, 111(27):9959-64. [Highlighted in the commentary of PNAS]
[Full text] [Full text]
Fang W.-Q., Chen W.-W., Fu A.K.Y., and Ip N.Y. (2013)
Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex.
Neuron, 79:665-679. [Highlighted in F1000Prime; and selected by Neuron to be accompanied with a video abstract. The video is featured on the Neuron website]
[Abstract] [Video Abstract] [Full text]
Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y. (2012)
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory.
Nat. Neurosci..15:1506-1515 [Highlighted in F1000Prime; and highlighted in News and Views of Nat. Neurosci.]
[Abstract] [Full text]
Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y., and Ip N.Y. (2012)
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.
Nat. Neurosci., 15:39-47. [Highlighted in F1000Prime]
[Abstract] [Full text]  
Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y. (2011)
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity.
Nat. Neurosci., 14: 181-9. [Featured in News and Views of Nat. Neurosci.]
[Abstract] [Full text]
Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., and Ip N.Y. (2011)
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease.
Nat. Cell Biol. 13:568-579.
[Abstract] [Full text]
Wan, J., Fu, A.K.Y., Ip, F.C.F., Ng, H.K., Hugon, J., Page, G., Wang, J.H., Lai, K.O., Wu, Z., and Ip, N.Y. (2010)
Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease.
J. Neurosci. 30(20): 6873-6881. [Highlighted in Alzheimer Research Forum]
[Abstract] [Full text]
Shi L., Butt B., Ip F.C.F., Dai Y., Jiang L., Yung W.H., Greenberg, M.E., Fu A.K.Y., and Ip N.Y. (2010)
Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction.
Neuron 65: 204–216. 
[Abstract] [Full text]
Fu W.Y., Chen Y., Sahin, M., Zhao X.S., Shi L., Bikoff, J.B., Lai K.O., Yung W.H., Fu A.K.Y., Greenberg, M.E., and Ip N.Y. (2007)
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
Nat. Neurosci. 10: 67-76. [Highlighted in Alzheimer Research Forum and in J. Cell Biol. (2007). 176(1): 5]
[Abstract] [Full text]
Cheung Z.H., Chin W.H., Chen Y., Ng Y.P., and Ip N.Y. (2007)
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.
PLoS Biol. 5(4) : 867-865.
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Shi L., Fu W.-Y., Hung K.W., Porchetta, C., Hall, C., Fu A.K.Y., and Ip N.Y. (2007)
α2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.
Proc. Natl. Acad. Sci. USA 104: 16347-16352.
[Full text] [Full text]
Sun L., Ma K., Wang H., Xiao F., Gao Y., Zhang W., Wang K., Gao X., Ip N.Y. and Wu, Z. (2007)
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts.
J. Cell Biol. 179: 129-138.
[Full text] [Full text]
Luo S., Chen Y., Lai K.O., Arevalo, J.C., Froehner, S., Adams, M.E., Chao M., and Ip, N.Y. (2005)
α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner.
J. Cell Biol. 169: 813-824.
[Full text] [Full text]
Fu A.K.Y., Ip F.C.F., Fu W.Y., Cheng J., Wang J., Yung W.H., and Ip N.Y. (2005)
Aberrant motor axon projection, AChR clustering and neurotransmission in cyclin-dependent kinase 5 null mice.
Proc. Natl. Acad. Sci. USA 102: 15224-15229.
[Full text] [Full text]
Fu A.K.Y., Fu W.Y., Ng A.K.Y., Chien W.W.Y., Ng Y.P., Wang J., and Ip N.Y. (2004)
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.
Proc. Natl. Acad. Sci. USA 101: 6728-6733.
[Full text] [Full text]
Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H., and Ip N.Y. (2001)
Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction.
Nature Neuroscience 4: 374-381. [Highlighted in News & Views of Nat. Neurosci.]
[Abstract] [Full text]
Ip N.Y., Boulton, T.G., Li, Y., Verdi, J.M., Birren, S.J., Anderson, D.J., and Yancopoulos, G.D. (1994)
CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons.
Neuron 13: 443-455.
Ip N.Y., McClain, J., Barrezueta, N., Aldrich, T.H., Pan, L., Li, Y., Wiegand, S.J., Friedman, B., Davis, S., and Yancopoulos, G.D. (1993)
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development.
Neuron 10: 89-102.
Ip N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene L.A., Barbacid, M., and Yancopoulos, G.D. (1993)
Similarities and differences in the way neurotrophins interact with the Trks in neuronal and nonneuronal cells. 
Neuron 10: 137-149.
Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D. (1992). 
Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity. 
Proc. Natl. Acad. Sci. 89: 3060-3064.
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Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D. (1992)
CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130.
Cell 69: 1121-1132.
Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip, N.Y. (1992)
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo. 
Neuron 9: 295-305.
Ip N.Y., and Zigmond, R.E. (1984)
Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event.
Nature 311: 472-474.
Ip N.Y., Perlman, R.L. and Zigmond, R.E. (1983)
Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms.
Proc. Natl. Acad. Sci. USA 80: 2081-2085.
[Full text]
Ip N.Y., Ho C.K. and Zigmond, R.E. (1982)
Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion.
Proc. Natl. Acad. Sci. USA 79: 7566-7569.
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