• Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification

    Huan Zhong, Xiaopu Zhou, Hyebin Uhm, Yuanbing Jiang, Han Cao, Yu Chen, Tiffany T. W. Mak, Ronnie Ming Nok Lo, Bonnie Wing Yan Wong, Elaine Yee Ling Cheng, Kin Y. Mok, Andrew Lung Tat Chan, Timothy C. Y. Kwok, Vincent C. T. Mok, Fanny C. F. Ip, John Hardy, Amy K. Y. Fu, Nancy Y. Ip
    Alzheimers Dement.  2024 Feb 7. doi: 10.1002/alz.13691.
    [Abstract]    [Full text]

  • A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.

    Yuanbing Jiang, Hyebin Uhm, Fanny C. Ip, Li Ouyang, Ronnie M. N. Lo, Elaine Y. L. Cheng, Xiaoyun Cao, Clara M. C. Tan, Brian C. H. Law, Paula Ortiz-Romero, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Kin Y. Mok, John Hardy, Timothy C. Y. Kwok, Vincent C. T. Mok, Marc Suárez-Calvet, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip
    Alzheimers Dement.  2024 Jan 6. doi: 10.1002/alz.13676. PMID: 38183344
    [Abstract]    [Full text]



  • An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

    Jiang Y., Zhou X., Wong H.Y., Ouyang L., Ip F.C.F., Chau M.N.V., Lau S.F., Wu W., Wong Y.K.D., Seo H., Fu W.Y., Lai C.H.N., Chen Y., Chen Y., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Mok C.Y.T., Shoai M., Lehallier B., Losada P.M., O’Brien E., Porter T., Laws S.M., Hardy J., Wyss-Coray T., Masters C.L., Fu A.K.Y. and Ip N.Y.
    Nature Aging  2, 616–634 (2022).
    [Abstract]    [Full text]

    [ALZFORUM]  Receptor Decoy Raises Risk of Alzheimer's — But Only in Women  

  • Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping

    Qin Z., She Z., Chen C., Wu W., Lau J.K.Y., Ip N.Y., Qu J.Y.
    Nat Biotechnol. 2022 Jun 13. doi: 10.1038/s41587-022-01343-w. PMID: 35697805
    [Abstract]    [Full text]

  • Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology

    Park J.C., Barahona-Torres N., Jang S.Y., Mok K.Y., Kim H.J., Han S.H., Cho K.H., Zhou X., Fu A.K.Y., Ip N.Y., Seo J., Choi M., Jeong H., Hwang D., Lee D.Y., Byun M.S., Yi D., Han J.W., Mook-Jung I., Hardy J.
    Adv Sci (Weinh). 2022 Jun 13;e2201212. doi: 10.1002/advs.202201212
    [Abstract]    [Full text]

  • Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer’s Disease Risk

    Cao H., Zhou X., Chen Y., Ip F.C.F., Chen Y., Lai N.C.H., Lo R.M.N., Tong E.P.S., Mok V.C.T., Kwok T.C.Y.; Alzheimer’s Disease Neuroimaging Initiative, Fu A.K.Y., Ip N.Y.
    J Alzheimers Dis. 2022;86(4):1861-1873. doi: 10.3233/JAD-215311. PMID: 35253752
    [Abstract]    [Full text]

  • Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong

    Wong H.Y., Zhong H., Zhong M., Zhou X., Chan P.Y.C., Kwok T.C.Y., Mok K., Hardy J., Ip F.C.F., Fu A.K.Y., Ip N.Y.
    J Alzheimers Dis. 2022 Apr 16. doi: 10.3233/JAD-215312. PMID: 35466936
    [Abstract]    [Full text]


  • Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population

    Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y.
    Alzheimers Dement.   2021 Dec;17 Suppl 3:e056625. doi: 10.1002/alz.056625. PMID: 35109110
    [Abstract]    [Full text]

  • AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

    Goertsen D., Flytzanis N.C., Goeden N., Chuapoco M.R., Cummins A., Chen Y., Fan Y., Zhang Q., Sharma J., Duan Y., Wang L., Feng G., Chen Y., Ip N.Y., Pickel J., Gradinaru V.
    Nat Neurosci. 2021 Dec 9. doi: 10.1038/s41593-021-00969-4. PMID: 34887588
    [Abstract]    [Full text]

  • A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D

    Wu M.Y., Wong A.Y.H., Leung J.K., Kam C., Wu K.L., Chan Y.S., Liu K., Ip N.Y. and Chen S.
    Proc Natl Acad Sci U S A;  2021 Nov 9;118(45):e2106143118. doi: 10.1073/pnas.2106143118. PMID: 34740969
    [Abstract]    [Full text]

  • Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model

    Fu W.Y., Hung K.W., Lau S.F., Butt B., Yuen V.W., Fu G., Chan I.C., Ip F.C.F., Fu A.K.Y. and Ip N.Y.
    ACS Chem Neurosci.  2021 Nov 5. doi: 10.1021/acschemneuro.1c00600. PMID: 34738783
    [Abstract]    [Full text]

  • A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice

    Ip F.C.F., Fu G., Yang F., Kang F., Sun P., Ling C.Y., Cheung K., Xie F., Hu Y., Fu L. and Ip N.Y.
    Eur J Med Chem. 2021 Sep 13;226:113827. doi: 10.1016/j.ejmech.2021.113827. PMID: 34530383
    [Abstract]    [Full text]

  • Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice

    Duan Y., Ye T., Qu Z., Chen Y., Miranda A., Zhou X., Lok K.C., Chen Y., Fu A.K.Y., Gradinaru V. and Ip N.Y.
    Nat Biomed Eng. 2021 Jul 26. doi: 10.1038/s41551-021-00759-0.PMID: 34312508
    [Abstract]    [Full text]

  • IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry

    Wang Y., Fu A.K.U. and Ip N.Y.
    DNA Cell Biol. 2021 Jul 22. doi: 10.1089/dna.2021.0491.

  • GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease

    Xu P., Chang J.C., Zhou X., Wang W., Bamkole M., Wong E., Bettayeb K., Jiang L.L., Huang T., Luo W., Xu H., Nairn A.C., Flajolet M., Ip N.Y., Li Y.M., Greengard P.
    J Exp Med. 2021 Aug 2;218(8):e20202446. doi: 10.1084/jem.20202446.
    [Abstract]    [Full text]

  • Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging

    Jiang Y., Zhou X., Ip F.C., Chan P., Chen Y., Lai N.C.H., Cheung K., Lo R.M.N., Tong E.P.S., Wong B.W.Y., Chan A.L.T., Mok V.C.T., Kwok T.C.Y., Mok K.Y., Hardy J., Zetterberg H., Fu A.K.Y. and Ip N.Y.
    Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12369.
    [Abstract]    [Full text]

  • IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease

    Lau S.F., Chen C., Fu W.Y., Qu J.Y., Cheung T.H., Fu A.K.Y. and Ip N.Y.
    Cell Rep. 2020 Apr 21;31(3):107530. doi: 10.1016/j.celrep.2020.107530.
    [Abstract]    [Full text]

  • Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model

    Lau J.K.Y., Tian M., Shen Y., Lau S.F., Fu W.Y., Fu A.K.Y. and Ip N.Y.
    Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4.
    [Abstract]    [Full text]

  • Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases

    Ye T., Duan Y., Tsang H.W.S., Chen Y., Cao H., Chen Y., Fu A.K.Y. and Ip N.Y.
    Communications Biology 4, Article number: 195 (2021)
    [Abstract]    [Full text]

  • Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model

    Lau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y.
    STAR Protocols STAR Protoc. 2021 Jan 13;2(1):100265. doi: 10.1016/j.xpro.2020.100265. eCollection 2021 Mar 19.
    [Abstract]    [Full text]

  • Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus

    Wang Y., Fu W.Y., Cheung K., Hung K.W., Chen C., Geng H., Yung W.H., Qu J.Y., Fu A.K.Y. and Ip N.Y.
    Proc. Natl. Acad. Sci. USA. January 5, 2021 118 (1) e2020810118;
    [Abstract]    [Full text]




  • In Vivo near-infrared two-photon imaging of amyloid plaques in deep brain of Alzheimer’s Disease mouse model

    Chen C., Liang Z., Zhou B., Li X., Lui C., Ip N.Y. and Qu J.
    ACS Chem. Neurosci.   DOI: 10.1021/acschemneuro.8b00306 Publication Date (Web): August 1, 2018
    [Abstract]    [Full text]

  • Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses

    Ng Y.P., Yip T.F., J.S. Malik Peiris, Ip N.Y. and Lee M.Y. Suki
    Journal of NeuroVirology   2018 Jul 9. doi: 10.1007/s13365-018-0659-8.

  • Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs

    Gu S., Fu W.Y., Fu A.K.Y., Tong E.P.S., Ip F.C.F., Huang X. and Ip N.Y.
    Scientific Reports   2018 May 9;8(1):7377. doi: 10.1038/s41598-018-25790-1.
    [Full text]    [Full text]

  • Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex–nucleus accumbens pathway in mice

    Cui Q., Li Q., Geng H., Chen L., Ip N.Y., Ke Y., and Yung W.H.
    Proc. Natl. Acad. Sci. USA.   2018 May 22;115(21):E4890-E4899. doi: 10.1073/pnas.1717106115. Epub 2018 May 7.
    [Full text]    [Full text]

  • Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

    Zhou X., Chen Y., Mok K.Y., Zhao Q., Chen K., Chen Y., Hardy J., Li Y., Fu A.K.Y., Guo Q., Ip N.Y. and for the Alzheimer’s Disease Neuroimaging Initiative
    Proc. Natl. Acad. Sci. USA.   February 20, 2018. 115 (8) 1697-1706; published ahead of print February 5, 2018;
    [Full text]    [Full text]


  • A new iridoid glycoside and a new cinnamoyl glycoside from Scrophularia ningpoensis Hemsl

    Zhang J., Ip F.C.F., Liang Y., Ip N.Y., Zhong B., Lai C.W., Xu S.
    Nat Prod Res.   2017 Oct;31(20):2361-2368. doi: 10.1080/14786419.2017.1306704. Epub 2017 Mar 22.

  • Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses

    Ng Y.P., Yip T.F., J.S. Malik Peiris, Ip N.Y. and Lee M.Y. Suki
    Journal of NeuroVirology   2018 Jul 9. doi: 10.1007/s13365-018-0659-8.

  • Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development

    Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y.
    Proc Natl Acad Sci USA.   August 15, 2017. 114 (33) E6992-E7001; published ahead of print July 31, 2017.
    [Full text]    [Full text]

  • Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response

    Ip F.C.F., Ng Y.P., Or C.T.T., Sun P., Fu G., Li Y.H.J., Ye W., Cheung T.H. and Ip N.Y.
    PLoS One.   2017 Jul 31;12(7):e0182069. doi: 10.1371/journal.pone.0182069. eCollection 2017.
    [Full text]    [Full text]

  • Diarylheptanoids from Rhizomes of Alpinia officinarum inhibit aggregation of alpha-synuclein

    Fu G., Zhang W., Du D., Ng Y.P., Ip F.C.F., Tong R. and Ip N.Y.
    J Agric Food Chem.   2017 Jul 14. doi: 10.1021/acs.jafc.7b02021.
    [Abstract]    [Full text]

  • Two pairs of unusual melibiose and raffinose esters from Scrophularia ningpoensis

    Zhang J., Liang Y., Ip F.C.F., Ip N.Y., Liu T., Zhong B. and Xu S.
    J Asian Nat Prod Res.   2017 May 24:1-8. doi: 10.1080/10286020.2017.1329301.


  • Stimulation of the hippocampal POMC/MC4R circuit alleviates synaptic plasticity impairment in an Alzheimer's Disease model

    Shen Y., Tian M., Zheng Y., Gong F., Fu A.K.Y. and Ip N.Y.
    Cell Rep.   2016 Nov 8;17(7):1819-1831. doi: 10.1016/j.celrep.2016.10.043.
    [Abstract]    [Full text]

  • Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats

    Ip F.C.F., Zhao Y., Chan K.W., Cheng E.Y., Tong E.P., Chandrashekar O., Fu G., Zhao Z. and Ip N.Y.
    BMC Complement Altern Med.   2016 Nov 4;16(1):437 DOI 10.1186/s12906-016-1417-1
    [Abstract]    [Full text]

  • China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing

    Poo M., Du J., Ip N.Y., Xiong Z., Xu P. and Tan T.
    Neuron   2016 Nov 2;92(3):591-596. doi: 10.1016/j.neuron.2016.10.050
    [Abstract]    [Full text]

  • The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines

    Liang Z., Zhan Y., Shen Y., Wong C.C., Yates J.R. 3rd, Plattner F., Lai K.O. and Ip N.Y.
    Nat. Commun.   7:13282, doi:10.1038/ncomms13282
    [Abstract]    [Full text]

  • Worldwide initiatives to advance brain research

    Grillner S., Ip N.Y., Koch C., Koroshetz W., Okano H., Polachek M., Poo M. and Sejnowski T.
    Nat. Neurosci.   19, 1118–1122 (2016) doi:10.1038/nn.4371
    [Full text]    [Full text]

  • Design and synthesis of dimeric securinine analogs with neuritogenic activities

    Tang G., Liu X., Ma N., Huang X., Wu Z.L., Zhang W., Wang Y., Zhao B., Wang Z., Ip F.C.F., Ip N.Y., Ye W.C., Shi L. and Chen W.M.
    ACS Chem Neurosci.   July 28, 2016 doi: 10.1021/acschemneuro.6b00188
    [Full text]    [Full text]

  • STAT3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration

    Zhu H., Xiao, F., Wang G., Wei X., Jiang L., Chen Y., Zhu L., Wang H., Diao Y., Wang H., Ip N.Y., Cheung T.H., and Wu Z.
    Cell Reports   2016 Aug 10. pii: S2211-1247(16)30959-7. doi: 10.1016/j.celrep.2016.07.041
    [Abstract]    [Full text]

  • New lignans with neuroprotective activity from Adelostemma gracillimum

    Zhang J., Guo S., Chan K.W., Tong E.P.S., Fu G., Mu Q., Ip F.C.F. and Ip N.Y.
    Phytochem. Let.   19 (9): 1-5.
    [Full text]    [Full text]

  • Multicolor 4D fluorescence microscopy using Ultrathin Bessel Light Sheets

    Zhao T., Lau S.C., Wang Y., Su Y., Wang H., Cheng A., Herrup K., Ip N.Y., Du S. and Loy M.M.
    Science Report   2016 May 18;6:26159. doi: 10.1038/srep26159.
    [Full text]    [Full text]

  • IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline

    Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y.
    Proc Natl Acad Sci USA.   May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016.
    [Full text]    [Full text]    [F1000 Prime Recommended]


  • Cdk5 regulates activity-dependent gene expression and dendrite development

    Liang Z., Ye T., Zhou X., Lai, K.O., Fu A.K.Y. and Ip N.Y.
    J. Neurosci.   11 November 2015, 35(45): 15127-15134; doi: 10.1523/JNEUROSCI.1443-15.2015
    [Abstract]    [Full text]

  • S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength

    Zhang P., Fu W.Y., Fu A.K.Y. and Ip N.Y.
    Nat. Commun.   6:8665. doi:10.1038/ncomms9665
    [Abstract]    [Full text]    [F1000 Prime Recommended]

  • Axin regulates dendritic spine morphogenesis through Cdc42-dependent signaling

    Chen Y., Liang Z., Fei E., Chen Y., Zhou X., Fang W., Fu W.Y., Fu A.K.Y. and Ip N.Y.
    PLoS One   2015 Jul 23;10(7):e0133115. doi: 10.1371/journal.pone.0133115.
    [Abstract]    [Full text]    [F1000 Prime Recommended]

  • Highly trans-selective arylation of Achmatowicz rearrangement products by reductive γ-Deoxygenation and Heck-Matsuda reaction: asymmetric total synthesis of (-)-musellarins A-C and their analogues

    Li Z., Ip F.C.F., Ip N.Y. and Tong R.
    Chemistry   2015 Jun 24. doi: 10.1002/chem.201501713.
    [Abstract]    [Full text]

  • Cdk5-dependent phosphorylation of p70 ribosomal S6 Kinase (S6K) is required for dendritic spine morphogenesis

    Lai K.O., Liang Z., Fei E.,Huang H., and Ip N.Y.
    J Biol Chem.   2015 Apr 22. doi: 10.1074/jbc.M114.627117
    [Abstract]    [Full text]

  • NRC-interacting factor directs neurite outgrowth in an activity-dependent manner

    Zhao X.S., Fu W.Y., Hung K.W., Chien W.W.Y., Li Z., Fu A.K.Y. and Ip N.Y.
    Neuroscience   2015 Mar 19;289:207-13. doi:10.1016/j.neuroscience.2014.12.041
    [Abstract]    [Full text]

  • Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection

    Ip F.C.F., Fu W.Y., Cheng E.Y.L., Tong E.P.S., LOK K.C., Liang Y., Ye W.-C. and Ip N.Y.
    Neuropsychopharmacology   2015 Feb 4. doi:10.1038/npp.2015.37
    [Abstract]    [Full text]


  • Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

    Fang W.-Q., Chen W.-W., Jiang L., Liu K., Yung W.H., Fu A.K.Y. and Ip N.Y.
    Cell Rep.   9(5):1635-43
    [Abstract]    [Full text]

  • p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1)

    Zhao X., Fu W.Y., Chien W.W.Y., Li Z., Fu A.K.Y. and Ip N.Y.
    PLoS One   2014 Oct 16;9(10):e110584. doi: 10.1371/journal.pone.0110584. eCollection 2014.
    [Abstract]    [Full text]

  • Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management

    Ip F.C.F., Ng Y.P., An H.J., Dai Y., Pang H.H., Hu Y.Q., Chin A.C., Harley C.B., Wong Y.H. and Ip N.Y.
    Neurosignals   2014;22(1):52-63. doi: 10.1159/000365290. Epub 2014 Jul 31.
    [Abstract]    [Full text]

  • Cdk5-mediated phosphorylation of ​RapGEF2 controls neuronal migration in the developing cerebral cortex

    Ye T., Ip J.P., Fu A.K.Y. and Ip N.Y.
    Nat. Commun.   5:4826. doi: 10.1038/ncomms5826
    [Abstract]    [Full text]

  • Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease

    Fu A.K.Y., Hung K.W., Huang H., Gu S., Shen Y., Cheng E.Y., Ip F.C.F., Huang X, Fu W.Y. and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   111(27):9959-64.
    [Abstract]    [Full text]    [Highlighted in the commentary of PNAS]

  • Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition

    Tang J., Ip J.P., Ye T., Ng Y.P., Yung W.H., Fu A.K.Y. and Ip N.Y.
    J. Neurosci.   34(22):7425-7436.
    [Abstract]    [Full text]    [This Week in The Journal]

  • Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton

    Chen Y., Ip F.C.F., Shi L., Zhang Z., Tang H., Ng Y.P., Ye W.-C., Fu A.K.Y. and Ip N.Y.
    J. Neurosci.   34(7):2413-2412.
    [Abstract]    [Full text]   


  • Melanocortin-4 receptor regulates hippocampal synaptic plasticity through PKA-dependent mechanism

    Shen Y., Fu, W.Y., Cheng E.Y.L., Fu A.K.Y. and Ip N.Y.
    J. Neurosci.   33(2):464-472.   
    [Abstract]    [Full text]   


  • TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

    Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y.
    Nat. Neurosci.   15:1506-1515   [Highlighted in F1000Prime]  [Highlighted in News and Views of Nat. Neurosci.]
    [Abstract]    [Full text]    [F1000 Prime Recommended]

  • Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development

    Chen Y., Fu W.Y., Ip J.P., Ye T., Fu A.K.Y., Chao M.V. and Ip N.Y.
    J. Neurosci.   32:8263-9.
    [Abstract]    [Full text]   

  • α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2

    Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y. and Ip N.Y.
    Nat. Neurosci.   15:39-47.   [Highlighted in F1000Prime]
    [Abstract]    [Full text]    [F1000 Prime Recommended]


  • Cdk5-mediated phosphorylation of axin directs axon formation during cerebral cortex development

    Fang W.-Q., Ip J.P., Li R., Ng Y.P., Lin S-C, Chen Y., Fu A.K.Y. and Ip, N.Y.
    J. Neurosci.   31(38):13613-24.
    [Abstract]    [Full text]   

  • APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

    Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y.
    Nat. Neurosci.   14: 181-9.   [Featured in News and Views of Nat. Neurosci.]
    [Abstract]    [Full text]   

  • Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

    Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H. and Ip N.Y.
    Nat. Cell Biol.   13:568-579.
    [Abstract]    [Full text]   


  • S-nitrosylation of cyclin-dependent kinase 5 (Cdk5) regulates its kinase activity and dendrite growth during neuronal development

    Zhang P., Yu P-C, Tsang A.H.K., Chen Y, Fu A.K.Y., Fu W.Y., Chung, K.K. and Ip N.Y.
    J. Neurosci.   30(43):14366-14370.
    [Abstract]    [Full text]   

  • Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease

    Wan, J., Fu A.K.Y., Ip F.C.F., Ng H.K., Hugon J., Page G., Wang J.H., Lai K.O., Wu Z. and Ip N.Y.
    J. Neurosci.   30(20): 6873-6881.  [Highlighted in Alzheimer Research Forum]
    [Abstract]    [Full text]   

  • Two Cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components

    Ou C.Y., Poon V.Y., Maeder C.I., Watanabe S., Lehrman E.K., Fu A.K.Y., Park M., Fu W.Y., Jorgensen E.M., Ip N.Y., and Shen K.
    Neuron   65: 204–216.
    [Abstract]    [Full text]   

  • Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction

    Shi L., Butt B., Ip F.C.F., Dai Y., Jiang L., Yung W.H., Greenberg, M.E., Fu A.K.Y. and Ip N.Y.
    Neuron   65: 204–216.
    [Abstract]    [Full text]    [F1000 Prime Recommended]   


  • Multiple Gi proteins participate in nerve growth factor-induced activation of c-jun N-terminal kinases in PC12 cells

    Tso P.H., Morris C.J., Yung L.Y., Ip N.Y., and Wong Y.H.
    Neurochemical Research   34: 1101-1112.
    [Abstract]    [Full text]   

  • Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK

    Hui K.P.Y., Lee S.M.Y., Cheung C.Y., Ng I.H.Y., Poon L.L.M., Guan Y., Ip N.Y., Lau A.S.Y., and Peiris, M.J.S.
    J. Immunol.   182:1088-1098.
    [Abstract]    [Full text]   

  • Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation

    Ng Y.P., Wu Z., Wise, H., Tsim K.W.K., Wong Y.H., and Ip N.Y.
    NeuroSignals   17: 111-120.
    [Abstract]    [Full text]   

  • Identification of retinoic acid-regulated nuclear matrix-associated protein (RAMP) as a novel regulator of gastric cancer

    Li J.J., Ng E.K., Ng Y.P., Wong C.Y.P., Yu J., Jin H.C., Cheng V.Y.Y., Go M.Y.Y., Cheung P.K.F., Man E.P.S., Ebert, M.P.A., Chan F.K.L. Sung J.J.Y., Ip N.Y., and Leung W.K.
    British Journal of Cancer   101: 691-698
    [Abstract]    [Full text]   

  • Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages

    Lee S., Gardy, J., Cheung C.Y., Cheung T., Hui K., Ip N.Y., Guan Y., Hancock, R., and Peirs, J.S.
    PLoS ONE   4(12): e8072
    [Abstract]    [Full text]   


  • Recent development in the search for effective antidepressants using traditional Chinese medicine

    Pang T.H.H., Ip F.C.F. and Ip N.Y.
    Central Nervous System Agents in Medicinal Chemistry   8:64-71.

  • Hyper-induction of COX-2 mediated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1

    Lee S.M.Y., Cheung C.Y., Nicholls, J.M., Hui K.P.Y., Leung C.Y.H., Uiprasertkul, M., Tipoe, G.L., Lau Y.L., Poon L.L.M., Ip N.Y., GuanY., and Peiris, M.J.S.
    J. Infectious Disease   198: 525-535.
    [Abstract]    [Full text]   

  • Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2

    Cheung Z.H., Ke G. and Ip N.Y.
    J. Neurosci   28: 4872-4877.
    [Abstract]    [Full text]   

  • Endophilin B1 as a novel regulator of nerve growth factor/TrkA trafficking and neurite outgrowth

    Wan J., Cheung A.Y., Fu W.Y., Wu C., Zhang M., Mobley, W.C., Cheung Z.H. and Ip N.Y.
    J. Neurosci   28: 9002-9012.
    [Abstract]    [Full text]   

  • Cdk5 activator p35 downregulates E-cadherin precursor independently of Cdk5

    Lin S., Wang J., Ye Z., Ip N.Y., Lin S.C.
    FEBS Lett.   582:1197-1202.
    [Abstract]    [Full text]   

  • Nerve growth factor-induced stimulation of p38 mitogen-activated protein kinase in PC12 cells is partially mediated via Gi/o protein

    Yung L.Y., Tso P.H., Wu E.H.T., Yu J.C.H., Ip N.Y. and Wong Y.H.
    Cellular Signalling   20:1538-1544.
    [Abstract]    [Full text]   


  • Minor limonoids from Melia toosendan and their antibacterial activity

    Zhang Q., Shi Y., Liu X.T., Liang J.Y., Ip N.Y., and Min Z.D.
    Planta Medica   73: 1298-1303.
    [Abstract]    [Full text]   

  • Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization

    Nguyen C., Hosokawa T., Kuroiwa M., Ip N.Y., Nishi A., Hisanaga S.I., and Bibb, J.A.
    Journal of Neurochemistry   103: 1582-1593.
    [Abstract]    [Full text]   

  • 一葉萩生物鹼類成分研究 (Alkaloids from Securinega suffruticosa)

    Wang Y., Li Q., Ye W.C., Ip F.C.F., Ip N.Y., and Zhao S.X.
    中草藥 (Chinese Traditional and Herbal Drugs)   38: 163-167.

  • Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons

    Cheung Z.H., Chin W.H., Chen Y., Ng Y.P. and Ip N.Y.
    PLoS Biol.   5(4) : 867-865.
    [Abstract]    [Full text]   

  • Expression of G protein β subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling

    Lok K.C., Fu A.K.Y., Ip F.C.F., Wong Y.H. and Ip N.Y.
    Neurosci.   146: 594-603.
    [Abstract]    [Full text]   

  • Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization

    Chan N., Hosokawa T., Ip N.Y., Hisanaga S., Bibb, J.A.
    J. Neurochem.   103:1582-1593.
    [Abstract]    [Full text]   

  • NRG induces membrane targeting of Gαz in muscle: implication in myogenesis

    Lok K.C., Fu A.K.Y., Ip F.C.F., Wong Y.H., and Ip N.Y.
    NeuroReport   18:1433-1436.

  • α2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse

    Shi L., Fu W.Y., Hung K.W., Porchetta, C., Hall, C., Fu A.K.Y., and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   104: 16347-16352.
    [Abstract]    [Full text]   

  • Antibacterial diterpenoids from Sagittaria pygmaea

    Liu X.T., Shi Y., Yu B., Williams, I.D., Sung H.H.Y., Zhang Q., Liang J.Y., Ip N.Y. and Min Z.D.
    Planta Med.   73: 84-90.
    [Abstract]    [Full text]   

  • JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts

    Sun L., Ma K., Wang H., Xiao F., Gao Y., Zhang W., Wang K., Gao X., Ip N.Y. and Wu Z.
    J. Cell Biol.   179: 129-138.
    [Abstract]    [Full text]   


  • Chemical constituents of Securinega suffruticosa

    Wang Y., Li Q., Ye W.C., Ip F.C.F., Ip N.Y. and Zhao S.X.
    Chinese Journal of Natural Medicines   4: 260-263.

  • Pctaire1 phosphorylates N-Ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis

    Liu Y., Cheng K., Ke G., Fu A.K.Y., and Ip N.Y.
    J. Biol. Chem.   281: 9852-9858.
    [Abstract]    [Full text]   

  • GABAB heterodimeric receptors promote Ca2+ influx via store-operated channels in transfected rat cortical neurons and transfected CHO cells

    New, D.C., An H., Ip N.Y. and Wong Y.H.
    Neuroscience   137: 1347-1358.
    [Abstract]    [Full text]   

  • ent-Rosane and labdane diterpenoids from Sagittaria sagittifolia and their antibacterial activity against three oral pathogens

    Liu X., Pan Q., Shi Y., Williams, I.D., Sung H.H., Zhang Q., Liang J., Ip N.Y. and Min Z.
    J. Nat. Prod.   69: 255-260.
    [Abstract]    [Full text]   

  • STAT3 as a downstream mediator of Trk signaling and functions

    Ng Y.P., Cheung Z.H., and Ip N.Y.
    J. Biol. Chem.   281: 15636-15644.
    [Abstract]    [Full text]   


  • Cytotoxic diterpenoids from the roots of Euphorbia ebracteolata

    Shi H.M., Williams, I.D., Sung H.H., Zhu H.X., Ip N.Y. and Min Z.
    Planta Medica   71: 349-54.
    [Abstract]    [Full text]   

  • A DNA microarray for the authentication of toxic traditional Chinese medicinal plants

    Carles, M., Cheung M.K.L., Moganti, S., Dong T.T.X., Tsim K.W., Ip N.Y. and Sucher, N.
    Planta Medica   71: 580-584.
    [Abstract]    [Full text]   

  • α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner

    Luo S., Chen Y., Lai K.O., Arevalo, J.C., Froehner, S., Adams, M.E., Chao M. and Ip N.Y.
    J. Cell Biol.   169: 813-824.
    [Abstract]    [Full text]   

  • Auto-inhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem

    Long J., Feng W., Wang R., Chan L.-N., Ip F.C.F., Xia J., Ip N.Y. and Zhang M.
    Nat. Struct. Biol.   12: 722-728.
    [Abstract]    [Full text]   

  • The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling

    He W., Gong K., Smith, D.K. and Ip N.Y.
    FEBS Letters   579: 4317-4323.
    [Abstract]    [Full text]   

  • Agrin regulates growth cone turning of Xenopus spinal motoneurons

    Xu X., Fu A.K.Y., Ip F.C.F., Wu C.-P., Duan, S., Poo M., Yuan, X. and Ip N.Y.
    Development   132: 4309-4316.
    [Abstract]    [Full text]   

  • Aberrant motor axon projection, AChR clustering and neurotransmission in cyclin-dependent kinase 5 null mice

    Fu A.K.Y., Ip F.C.F., Fu W.Y., Cheng J., Wang J., Yung W.H. and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   102: 15224-15229.
    [Abstract]    [Full text]   

  • SLAM-associated protein (SAP) as a potential negative regulator in Trk signaling

    Lo K.Y., Chin W.H., Ng Y.P., Cheng W., Cheung Z.H. and Ip N.Y.
    J. Biol. Chem.   280: 41744-41752.
    [Abstract]    [Full text]   


  • Melia toosendan regulates PC12 cell differentiation via the activation of a PKA-dependent ERK signaling pathway

    Yu J.C.H., Min Z. and Ip N.Y.
    NeuroSignals   13: 248-257.
    [Abstract]    [Full text]   

  • Activity of macrocyclic jatrophane diterpenes from Euphorbia kansui in a TrkA fibroblast survival assay

    Pan Q., Ip F.C.F., Ip N.Y., Zhu H. and Min Z.
    J. Nat. Prod.   67: 1548-1551.
    [Abstract]    [Full text]   

  • Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription

    Li Z., David, G., Hung K.W., DePinho, R.A., Fu A.K.Y. and Ip, N.Y.
    J. Biol. Chem.   279: 54438-54444.
    [Abstract]    [Full text]   

  • Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression

    Lai K.O., Chen Y., Po H.-M., Lok K.C., Gong K. and Ip N.Y.
    J. Biol. Chem.   279: 13383-13392.
    [Abstract]    [Full text]   

  • Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

    Fu A.K.Y., Fu W.Y., Ng A.K.Y., Chien W.W.Y., Ng Y.P., Wang J. and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   101: 6728-6733.
    [Abstract]    [Full text]   


  • Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons

    Ng Y.P., He W., and Ip N.Y.
    J. Biol. Chem.   278: 38731-38739.
    [Abstract]    [Full text]   

  • Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free association among components of the CNTF receptor complex

    Man, D., He W., Sze K.H., Gong K., Smith, D.K., Zhu G., and Ip N.Y.
    J. Biol. Chem.   278: 23285-23294.
    [Abstract]    [Full text]   

  • Ephrin-B1 reverse signaling activates JNK through a novel mechanism that is independent of tyrosine phosphorylation

    Xu Z., Lai K.O., Zhou H.M., Lin S.C. and Ip N.Y.
    J. Biol. Chem.   278: 24767-24775.
    [Abstract]    [Full text]   


  • Induction of Cdk5 activity in rat skeletal muscle after nerve injurys

    Fu W.Y., Fu A.K.Y., Lok K.C., Ip F.C.F. and Ip N.Y.
    NeuroReport   13: 243-247.

  • Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro

    He W., Gong K., Zhu G., Smith, D.K. and Ip N.Y.
    FEBS Letters   514: 214-218.
    [Abstract]    [Full text]   

  • Expression of Cdk5 and its activators in NT2 cells during neuronal differentiation

    Fu W.Y., Wang J.H. and Ip N.Y.
    J. Neurochem.   81: 646-654.
    [Abstract]    [Full text]   

  • Pctaire-1 interacts with p35 and is a novel substrate for Cdk5

    Cheng K., Li Z., Fu W.Y., Wang J.H., Fu A.K.Y. and Ip N.Y.
    J. Biol. Chem.   277: 31988-31993.
    [Abstract]    [Full text]   

  • Genotyping on a complementary metal oxide semiconductor silicon PCR chip with integrated DNA microarray

    Trau, D., Lenigk, R., Lao A.I.K., Lee T.M.H., Hsing I., Ip N.Y., Carles, M.C. and Sucher, N.
    Analytical Chem.   74: 3168-3173.


  • A reporter gene assay for the detection of phytoestrogens in traditional Chinese medicine

    Miller-Martini, D.M., Chan R.Y.K., Ip N.Y., Sheu S.J., and Wong Y.H.
    Phytotherapy Research   15: 487-492.
    [Abstract]    [Full text]   

  • The expression profiles of neurotrophins and their receptors in rat and chicken tissues during development

    Ip F.C.F., Cheung J. and Ip N.Y.
    Neurosci. Lett.   301: 107-110.
    [Abstract]    [Full text]   

  • Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction

    Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H. and Ip N.Y.
    Nat. Neurosci.   4: 374-381.
    [Abstract]    [Full text]   

  • Cloning and expression of a novel nuclear matrix associated protein that is regulated during the retinoic acid induced neuronal differentiation

    Cheung W.M.W., Chu A.H., Chu P.W.K. and Ip N.Y.
    J. Biol. Chem.   276: 17083-17091.
    [Abstract]    [Full text]   

  • Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction

    Lai K.O., Ip F.C.F., Cheung J., Fu A.K.Y. and Ip N.Y.
    Mol. Cell. Neurosci.   17: 1034-1047.
    [Abstract]    [Full text]   

  • Surface characterization of a silicon-based DNA microarray

    Lenigk, R., Carles, M., Ip N.Y. and Sucher, N.J.
    Langmuir   17: 2497-2501.

  • Expression of P2Y1 nucleotide receptors in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptors

    Choi R.C.Y., Man M.L.S., Ling K., Ip N.Y., Simon, J., Barnard, E.A. and Tsim K.W.K.
    J. Neurosci.   21: 9224-9234.
    [Abstract]    [Full text]   

  • Overexpression of muscle specific kinase increases the transcription and aggregation of acetylcholine receptors in Xenopus embryos

    Fu A.K.Y., Cheung J., Xie P., Smith F.D. and Ip N.Y.
    Mol. Brain Res.   96: 21-29.
    [Abstract]    [Full text]   

  • Complete 1H, 15N and 13C assignments of the carboxylterminal domain of the ciliary neurotrophic factor receptor (CNTFR)

    Man, D., Xia Y., Sze K.H., Smith D., He W., Ip N.Y. and Zhu G.
    J. Biomolecular NMR   22: 95-96.


  • Synergistic effects of muscarinic agonists and secretin or vasoactive intestinal peptide on the regulation of tyrosine hydroxylase activity in sympathetic neurons

    Ip N.Y. and Zigmond, R.E.
    J. Neurobiol  42: 14-21.
    [Abstract]    [Full text]

  • Induction of TrkA expression by differentiation inducers in human myeloid leukemia KG-1 cells

    Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
    Leukemia & Lymphoma  36: 595-601.

  • IL-6 enhanced the retinoic acid-induced differentiation of human acute promyelocytic leukemia cells

    Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
    Cancer Lett  148: 207-213.
    [Abstract]    [Full text]

  • Nerve growth factor potentiated the sodium butyrate- and PMA- induced megakaryocytic differentiation of K562 leukemia cells

    Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
    Leukemia Res  24: 751-759.
    [Abstract]    [Full text]

  • Developmental and tissue-specific expression of DEAD box protein p72

    Ip F.C.F., Chung S.S.K., Fu W.Y., and Ip N.Y.
    NeuroReport  11: 457-462.

  • Precise temperature control of microfluidic chamber for gas and liquid phase reactions

    Lao A.I.K., Lee T.M.H., Hsing I. and Ip N.Y.
    Sensors and Actuators  84: 11-17.

  • Altered expression of tissue-type plasminogen activator and type 1 inhibitor in astrocytes following injury

    Tang H., Fu W.Y. and Ip N.Y.
    Neurosci. Lett.  285: 143-146.
    [Abstract]    [Full text]

  • Expression of retinoid receptors during the retinoic acid induced neuronal differentiation of a human embryonal carcinoma cell line

    Cheung W.M.W., Chu P.W.K., Lung C.H. and Ip N.Y.
    J. Neurochem.   75: 34-40.
    [Abstract]    [Full text]

  • Identification and characterization of differentially expressed genes in denervated muscle

    Tang H., Cheung W.M.W., Ip F.C.F. and Ip N.Y.
    Mol. Cell. Neurosci.  16: 127-140.
    [Abstract]    [Full text]

  • Ganoderma extract activates MAP kinase and induces the neuronal differentiation of rat pheochromocytoma PC12 cells

    Cheung W.M.W., Hui W.S., Chu P.W.K., Chiu S.W. and Ip N.Y.
    FEBS Letters  486: 291-296.
    [Abstract]    [Full text]

  • A J-multiplied HMQC (MJ-HMQC) experiment for measuring (3) J (HNA alpha) coupling constants

    Xia Y.L., Kong X.M., Ip N.Y., and Zhu G.
    J. Magnetic Resonance  146: 228-231.


  • Xenopus muscle specific kinase: molecular cloning and prominent expression in neural tissues during early embryonic development

    Fu A.K.Y., Smith, F.D., Zhou H., Chu A.H., Tsim K.W.K., Peng H.B. and Ip N.Y.
    Eur. J. Neurosci.  11: 373-382.
    [Abstract]    [Full text]

  • A cysteine-rich form of Xenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes

    Yang J.F., Zhou H., Choi R.C.Y., Ip N.Y., Peng H.B. and Tsim K.W.K.
    Mol. Cell. Neurosci.  13: 415-429.
    [Abstract]    [Full text]

  • Production of human CNS neurons from embryonal carcinoma cells using a cell aggregation method

    Cheung W.M.W., Fu W.Y., Hui W.S. and Ip N.Y.
    Biotechniques  26: 946-954.

  • Identification of genes induced by neuregulin in cultured myotubes

    Fu A.K.Y., Cheung W.M.W., Ip F.C.F. and Ip N.Y.
    Mol. Cell Neurosci.  14: 241-253.
    [Abstract]    [Full text]

  • Identification and characterization of splice variants of ephrin-A3 and ephrin-A5

    Lai K.O., Ip F.C.F. and Ip N.Y.
    FEBS Lett.  458: 265-269.
    [Abstract]    [Full text]

  • Induction of gp130 and LIF by differentiation inducers in human myeloid leukemia K562 cells

    Xie P., Chan F.S.L., Ip N.Y. and Leung M.F.
    Leukemia Res.  23: 1113-1119.
    [Abstract]    [Full text]


  • Cloning and expression of a novel neurotrophin, NT-7, from carp

    Lai K.O., Fu W.Y., Ip F.C.F. and Ip N.Y.
    Mol. Cell. Neurosci.  11: 64-76.
    [Abstract]    [Full text]

  • Induction of NG108-15 cells differentiation by human bone marrow stromal cells

    Ho S.H., So L.H., Lai K.O., Ip N.Y. and Leung M.F.
    NeuroReport  9: 1365-1369.

  • Cloning of cDNAs encoding Xenopus neuregulin: Expression in myotomal muscle during embryo development

    Yang J.F., Zhou H., Pun S., Ip N.Y., Peng B. and Tsim K.W.K.
    Mol Brain Res.  58: 59-73.

  • Expression of BDNF and TrkB with age and age-related memory deficits

    Croll, S.D., Ip N.Y., Lindsay, R.M. and Wiegand, S.J.
    Brain Research  812: 200-208.
    [Abstract]    [Full text]


  • Trauma-induced striatal CNTF and BDNF mRNA in hemiparkinsonian rats

    Plunkett, R.J., Ip N.Y., Asada H., Friedman, B., Pan, L., Kaseloo, P.A. and Parfitt, M.M.
    NeuroReport  8: 507-511.

  • The EGF-like domain of chick acetylcholine receptor-inducing activity (ARIA) contains its full biological activity

    Yang J.F., Ng Y.P., Pun S., Ip N.Y. and Tsim K.W.K.
    FEBS Letters  403: 163-167.
    [Abstract]    [Full text]

  • Identification of candidate genes induced by retinoic acid in embryonal carcinoma cells

    Cheung W.M.W., Chu A.H. and Ip N.Y.
    J. Neurochem.  68: 1882-1888.
    [Abstract]    [Full text]

  • Induction of TrkA receptor by retinoic acid in leukemia cell lines

    Xie P., Cheung W.M.W., Ip F.C.F., Ip N.Y. and Leung, M.F.
    NeuroReport  8: 1067-1070.

  • Chick muscle expresses various ARIA isoforms: Regulation during development, denervation and regeneration

    Ng Y.P., Pun S., Ip F.C.F., Ip N.Y. and Tsim K.W.K.
    Mol. Cell. Neurosci.  9: 132-143.
    [Abstract]    [Full text]

  • Agrin-deficient myotube retains its AChR aggregation ability when challenged with agrin

    Pun S., Ng Y.P., Yan, J.F., Ip N.Y. and Tsim K.W.K.
    J. Neurochem  69: 2555-2563.
    [Abstract]    [Full text]

  • Muscle-derived neurotrophin-3 increases the aggregation of acetylcholine receptors in neuron-muscle co-cultures

    Fu A.K.Y., Ip F.C.F., Lai K.O., Tsim K.W.K. and Ip N.Y.
    NeuroReport  8: 3895-3900.


  • Induction of trk receptors by retinoic acid in a human embryonal carcinoma cell line

    Cheung W.M.W., Chu A.H., Leung M.F. and Ip N.Y.
    NeuroReport  7: 1204-1208.

  • Differential expression of ciliary neurotrophic factor receptor in skeletal muscle of chick and rat after nerve injury

    Ip F.C.F., Fu A.K.Y., Tsim K.W.K. and Ip N.Y.
    J. Neurochem.  67: 1607-1612.
    [Abstract]    [Full text]

  • Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras

    Lai K.O., Glass, D.J., Yancopoulos, G.D. and Ip N.Y.
    J. Neurosci. Res.  46: 618-629.
    [Abstract]    [Full text]


  • Binding characteristics of ciliary neurotrophic factor to sympathetic neurons and neuronal cell lines

    Wong V., Pearsall, D., Arriaga R., Ip N.Y., Stahl N., and Lindsay, R.M.
    J. Biol. Chem.  270: 313-318.
    [Abstract]    [Full text]

  • Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor

    Valenzuela, D.M., Rojas E., Le Beau, M.M., Espinosa III., R., Brannan, C.I., McClain, J., Masiakowski, P., Ip N.Y., Copeland, N.G., Jenkins, N.A., and Yancopoulos, G.D.
    J. Biol. Chem.  270: 313-318.
    [Abstract]    [Full text]

  • Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum

    Asada H., Ip N.Y., Pan, L., Razack, N., Parfitt, M.M. and Plunkett, R.J.
    J. Neurosci. Res.  40: 22-30.
    [Abstract]    [Full text]

  • Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family

    Valenzuela, D.M., Rojas, E., Griffiths, J.A., Compton, D.L., Gisser, M., Ip N.Y., Goldfarb, M. and Yancopoulos, G.D.
    Oncogene  10: 1573-1580.

  • Identification of mammalian noggin and its expression in the adult nervous syste

    Valenzuela, D.M., Economides, A.N., Rojas, E., Lamb, T.M., Nunes, L., Jones, P., Ip N.Y., Espinosa, III, R., Brannan, C.I., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Le Beau, M.M., Harland, R.M. and Yancopoulos, G.D.
    J. Neurosci.  15: 6077-6084.
    [Full text]

  • Neurotrophin-3 augments steroid secretion by hamster ovarian follicles

    Waraksa, J.A., Lindsay, R.M., Ip N.Y. and Hutz, R.J.
    in vitro. Zool. Sci.  12: 499-502.
    [Full text]

  • Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4.

    Conover, J.C., Erickson, J.T., Katz, D.M., Bianchi, L.M., Poueymirou, W.T., McClain, J., Pan, L., Helgren, M., Ip N.Y., Boland, P., Friedman, B., Weigand, S., Vejsada, R., Kato, A., DeChiara, T.M. and Yancopoulos, G.D.
    Nature  375: 235-238.

  • Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

    DeChiara, T.M., Vejsada, R., Pouyemirou, W.T., Acheson, A., Suri, C., Conover, J.C., McClain, J., Pan, L., Stahl, N., Ip N.Y., Kato, A., and Yancopoulos, G.D.
    Cell  83: 313-322.
    [Abstract]    [Full text]

  • Cloning of the a component of the chick ciliary neurotrophic factor receptor: developmental expression and downregulation in denervated skeletal muscle

    Ip F.C.F., Fu A.K.Y., Tsim K.W.K. and Ip N.Y.
    J. Neurochem.  65: 2393-2400.


  • Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

    Stahl, N., Boulton, T.G., Farruggella, T., Ip N.Y., Davis, S., Witthuhn, B., Quelle, F.W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J.N. and Yancopoulos, G.D.
    Science  263: 92-95.

  • Overlapping and distinct actions of the neurotrophins, BDNF, NT-3 and NT-4/5, on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon

    Hyman, C., Juhasz, M., Jackson, C., Wright, P., Ip N.Y., and Lindsay, R.M.
    J. Neurosci.  14: 335-347.
    [Full text]

  • Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve

    Curtis, R., Scherer, S.S., Somogyi, R., Adryan, K.M., Ip N.Y., Zhu Y., Lindsay, R.M. and DiStefano, P.S.
    Neuron  12: 191-204.

  • Leukemia inhibitory factor and neurotrophins support overlapping populations of rat nodose sensory neurons in culture

    Thaler, C., Suhr, L., Ip N.Y., and Katz, D.
    Developmental Biology  161: 338-344.

  • Neurotrophic factor receptors and their signal transduction capabilities in astrocytes

    Rudge, J.S., Li, Y., Pasnikowski, E.M., Mattsson, K., Pan, L., Yancopoulos, G.D., Wiegand, S.J., Lindsay, R.M. and Ip N.Y.
    Eur. J. Neurosci.  6: 693-705.

  • The tails of two proteins: the scrapie prion protein and the ciliary neurotrophic factor receptor

    Stahl, N., Boulton, T.G., Ip N.Y., Davis, S., and Yancopoulos, G.D.
    Brazilian J. Med. Biol. Res.  27: 297-301.

  • Expression of p140 trk in MAH cells lacking p75LNGFR is sufficient to permit NGF-induced differentiation to post-mitotic neurons

    Verdi, J.M., Ip N.Y., Yancopoulos, G.D., and Anderson, D.J.
    Proc. Natl. Acad. Sci. USA  91: 3949-3953.
    [Full text]

  • CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons

    Ip N.Y., Boulton, T.G., Li, Y., Verdi, J.M., Birren, S.J., Anderson, D.J. and Yancopoulos, G.D.
    Neuron  13: 443-455.

  • in situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high affinity binding of [125I]BDNF, [125I]NT-4/5 and [125I]-NT-3

    Altar, C.A., Siuciak, J.A., Wright, P., Lindsay, R.M., Ip N.Y. and Wiegand, W.J.
    Eur. J. Neurosci.  6: 1389-1405.

  • Neurotrophic factors collaborate to drive differentiation of neuronal progenitor cells

    Ip N.Y.
    Neurosci. Lett.  45: 52.


  • Cloning and analysis of neurotrophic factor receptors using function-based strategies

    Glass, D.J., Gies, D.R., Stitt, T.N., Davis, S., Hantzopoulos, P., Ip N.Y., Goldfarb, M., and Yancopoulos, G.D.
    Cold Spring Harbor Symposia on Quantitative Biology  57: 53-62.

  • The neurotrophins BDNF, NT-3, and NT-4, but not NGF, up-regulate the cholinergic phenotypic of developing motor neurons

    Wong V., Arriaga, R., Ip N.Y. and Lindsay, R.M.
    Eur. J. Neurosci.  5: 466-474.

  • Released form of CNTF receptor α component as a soluble mediator of CNTF responses

    Davis, S., Aldrich, T.H., Ip N.Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., and Yancopoulos, G.D.
    Science  259: 1736-1739.

  • Injury-induced regulation of CNTF mRNA in the adult rat brain

    Ip N.Y., Morse, J.K., Wiegand, S.J. and Rudge, J.S.
    Eur. J. Neurosci.  5: 25-33.

  • The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

    Ip N.Y., McClain, J., Barrezueta, N., Aldrich, T.H., Pan, L., Li, Y., Wiegand, S.J., Friedman, B., Davis, S., and Yancopoulos, G.D.
    Neuron  10: 89-102.

  • Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion

    Ibanez, C.F., Ernfors, P., Timmusk, T., Ip N.Y., Arenas, E., Yancopoulos, G.D., and Persson, H.
    Development  117: 1345-1353.
    [Full text]

  • Alternate forms of rat TrkC with different functional capabilities

    Valenzuela, D.M., Maisonpierre, P.C., Glass, D.J., Rojas, E., Nunez, L., Kong, Y., Gies, D.R., Stitt, T.N., Ip N.Y. and Yancopoulos, G.D.
    Neuron  10: 963-974.

  • Crosslinking of CNTF and LIF to endogenous and reconstructed receptor complexes identifies LIF binding protein as a CNTF receptor component

    Stahl, N., Davis, D., Wong, V., Taga, T., Tadamitsu, K., Ip N.Y. and Yancopoulos, G.D.
    J. Biol. Chem.  268: 7628-76.
    [Abstract]    [Full text]

  • LIFR β and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

    Davis, S., Aldrich, T., Stahl, N., Pan L., Taga, T., Kishimoto, K., Ip N.Y. and Yancopoulos, G.D.
    Science  260: 1805-1808.

  • Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF

    Lohof, A.M., Ip N.Y. and Poo M.
    Nature  363: 350-353.

  • Cultured hippocampal neurons show responses to BDNF, NT-3 and NT-4 but not NGF

    Ip N.Y., Li Y., Yancopoulos, G.D. and Lindsay, R.M.
    J. Neurosci.  13: 3394-3405.
    [Full text]

  • Ciliary neurotrophic factor maintains pluripotentiality of embryonic stem cells

    Conover, J.C., Ip N.Y., Poueymirou, W.T., Bates, B., Goldfarb, M.P., DeChiara, T.M., and Yancopoulos, G.D.
    Development  119: 559-565.
    [Abstract]    [Full text]

  • Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3

    Sofroniew, M.V., Cooper, J.D., Svendsen, C.N., Crossman, P., Ip N.Y., Lindsay, R.M., Zafra, F., and Lindholm, D.
    J. Neurosci.  13: 5263-5276.
    [Full text]


  • Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity

    Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D.
    Proc. Natl. Acad. Sci. USA  89: 3060-3064.
    [Full text]

  • Expression of ciliary neurotrophic factor and the neurotrophins - Nerve growth factor, brain derived neurotrophic factor and neurotropin3- in cultured rat hippocampal astrocytes

    Rudge, J.S., Alderson, R.F., Pasnikowski, E., McClain, J., Ip N.Y. and Lindsay, R.M.
    Eur. J. Neurosci.  4: 459-471.

  • K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses

    Nye, S.H., Squinto S.P., Glass, D.J., Stitt, T.N., Hantzopoulos, P., Macchi, M.J., Lindsay, N.S., Ip N.Y. and Yancopoulos, G.D.
    Mol. Biol. Cell  3: 677-686.
    [Abstract]    [Full text]

  • CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130

    Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D.
    Cell  69: 1121-1132.

  • Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

    Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip N.Y.
    Neuron  9: 295-305.


  • Human and rat BDNF and NT-3: Gene structures, distributions and chromosomal localizations

    Maisonpierre, P.C., Le Beau, M.M., Espinosa III, R., Ip N.Y., Belluscio, L., de la Monte, S.M., Squinto, S., Furth, M.E. and Yancopoulos, G.D.
    Genomics  10: 558-568.

  • Erks: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

    Boulton, T.G., Nye, S.H., Robbins, D.J., Ip N.Y., Radziejewska, E., Morgenbesser, S.D., DePinho, R.A., Panayotatos, N., Cobb, M.H., and Yancopoulos, G.D.
    Cell  65: 663-675.

  • The neurotrophin family of NGF-related neurotrophic factors

    Lindsay, R.M., Alderson, R.F., Friedman, B., Hyman, C., Ip N.Y., Furth, M.E., Maisonpierre, P.C., Squinto, S.P. and Yancopoulos, G.D.
    Restorative Neurology and Neuroscience  2: 211-220.
    [Full text]

  • Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

    Ip N.Y., Li, Y., van de Stadt, I., Panayotatos, N., Alderson, R.F., and Lindsay, R.M.
    J. Neurosci.  11: 3124-3134.
    [Full text]

  • The neurotrophins and CNTF: Specificity of action towards PNS and CNS neurons

    Ip N.Y., Maisonpierre, P., Alderson, R., Friedman, B., Furth, M.E., Panayotatos, N., Squinto, S., Yancopoulos, G.D. and Lindsay, R.M.
    J. Physiol., Paris  85: 123-130.


  • DNA linkage analysis and studies of the androgen receptor gene in a large kindred with complete androgen insensitivity

    Imperato-McGinley, J., Ip N.Y., Gautier, T., Neuweiler, J., Gruenspan, H., Liao, S., Chang, C., and Balazs, I.
    Am. J. of Med. Genet.  36: 104-108.

  • Neurotrophin-3: a neurotrophic factor related to NGF and BDNF

    Maisonpierre, P.C., Belluscio, L., Squinto, S., Ip N.Y., Furth, M.E., Lindsay, R.M., and Yancopoulos, G.D.
    Science  247: 1446-1451.

  • Neurotrophic factors, their receptors, and the signal transduction pathways they activate

    Yancopoulos, G.D., Maisonpierre, P.C., Ip N.Y., Aldrich, T.H., Belluscio, L., Boulton, T.G., Cobb, M.H., Squinto, S.P. and Furth, M.E.
    Cold Spring Harbor Symposia on Quantitative Biology  55: 371-379.


  • Activation of ganglionic tyrosine hydroxylase by peptides of the glucagon-secretin family: Structure-function studies

    Schwarzchild, M.A., Vale, W., Corigliano-Murphy, A.C., Pisano, J.J., Ip N.Y. and Zigmond, R.E.
    Neuroscience  31: 159-167.

  • Identification and Characterization of a hypervariable region [D18S27] on chromosome 18

    Ip N.Y., van de Stadt, I., Loewy, Z., Leary, S., Grzeschik, K. and Balazs, I.
    Nuc. Acids. Res.  17: 8404.
    [Full text]

  • Discovery of a novel multilocus DNA polymorphism

    Ip N.Y., Nicholas, L., Baum, H. and Balazs, I.
    Nuc. Acids. Res.  17: 4427.
    [Full text]


  • Long-term regulation of tyrosine hydroxylase activity in the superior cervical ganglion in organ culture: Effects of nerve stimulation and dexamethasone

    Ip N.Y. and Zigmond, R.E.
    Brain Research  338: 61-70.

  • Regulation of the concentration of cAMP and the activity of tyrosine hydroxylase in the rat superior cervical ganglion by three neuropeptides of the secretin family

    Ip N.Y., Baldwin, C. and Zigmond, R.E.
    J. Neuroscience  5: 1947-1954.
    [Full text]


  • Acute stimulation of ganglionic tyrosine hydroxylase activity by secretin, VIP and PHI

    Ip N.Y., Baldwin, C. and Zigmond, R.E.
    Peptides  5: 309-312.

  • Substance P inhibits the acute stimulation of ganglionic tyrosine hydroxylase activity by a nicotinic agonist

    Ip N.Y. and Zigmond, R.E.
    Neuroscience  13: 217-220.

  • Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event

    Ip N.Y. and Zigmond, R.E.
    Nature  311: 472-474.


  • Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms

    Ip N.Y., Perlman, R.L. and Zigmond, R.E.
    Proc. Natl. Acad. Sci. USA  80: 2081-2085.
    [Full text]


  • Both nicotinic and muscarinic agonists acutely increase tyrosine 3-m, onooxgenase activity in the superior cervical ganglion

    Ip N.Y., Perlman, R.L. and Zigmond, R.E.
    J. Pharmacol. Exp. Ther.  223: 280-283.
    [Abstract]    [Full text]

  • Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion

    Ip N.Y., Ho, C.K. and Zigmond, R.E.
    Proc. Natl. Acad. Sci. USA  80: 2081-2085.
    [Full text]


  • Characterization and regulation of receptors for epidermal growth factor in mouse calvaria

    Shupnik, M.A., Ip N.Y. and Tashjian, A.H., Jr.
    Endocrinology  107: 1738-1746.