Zhou X., Chen Y., Mok K.Y., Zhao Q., Chen K., Chen Y., Hardy J., Li Y., Fu A.K.Y., Guo Q., Ip N.Y. and for the Alzheimer’s Disease Neuroimaging Initiative Proc. Natl. Acad. Sci. USA. February 20, 2018. 115 (8) 1697-1706; published ahead of print February 5, 2018; https://doi.org/10.1073/pnas.1715554115. [Full text] [Full text]
Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y. Proc. Natl. Acad. Sci. USA. August 15, 2017. 114 (33) E6992-E7001; published ahead of print July 31, 2017. https://doi.org/10.1073/pnas.1708240114 [Full text] [Full text]
IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline
Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y. Proc. Natl. Acad. Sci. USA. May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016. https://doi.org/10.1073/pnas.1604032113 [Full text] [Full text] [F1000 Prime Recommended]
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory
Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y. Nat. Neurosci. 15:1506-1515 [Highlighted in F1000Prime] [Highlighted in News and Views of Nat. Neurosci.] [Abstract] [Full text] [F1000 Prime Recommended]
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2
Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y., and Ip N.Y. Nat. Neurosci. 15:39-47. [Highlighted in F1000Prime] [Abstract] [Full text] [F1000 Prime Recommended]
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y. Nat. Neurosci. 14: 181-9. [Featured in News and Views of Nat. Neurosci.] [Abstract] [Full text]
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., and Ip N.Y. Nat. Cell Biol. 13:568-579. [Abstract] [Full text]
Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction
Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H., and Ip N.Y. Nat. Neurosci. 4: 374-381. [Hightlighted in News & Views Nat. Neurosci.] [Abstract] [Full text]
CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons
Ip N.Y., Boulton, T.G., Li Y., Verdi, J.M., Birren, S.J., Anderson, D.J., and Yancopoulos, G.D. Neuron 13: 443-455. [Abstract]
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
Ip N.Y., McClain, J., Barrezueta, N., Aldrich, T.H., Pan, L., Li Y., Wiegand, S.J., Friedman, B., Davis, S., and Yancopoulos, G.D. Neuron 10: 89-102. [Abstract]
Similarities and differences in the way neurotrophins interact with the Trks in neuronal and nonneuronal cells
Ip N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene L.A., Barbacid, M., and Yancopoulos, G.D. Neuron 10: 137-149. [Abstract]
Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity
Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D. Proc. Natl. Acad. Sci. USA 89: 3060-3064. [Full text]
CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130
Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D. Cell 69: 1121-1132. [Abstract]
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip, N.Y. Neuron 9: 295-305. [Abstract]
Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event
Ip N.Y., and Zigmond, R.E. Nature 311: 472-474. [Abstract]
Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms
Ip N.Y., Perlman, R.L. and Zigmond, R.E. Proc. Natl. Acad. Sci. USA 80: 2081-2085. [Full text]
Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion
Ip N.Y., Ho C.K. and Zigmond, R.E. Proc. Natl. Acad. Sci. USA 79: 7566-7569. [Full text]
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
Zhou X., Chen Y., Mok K.Y., Zhao Q., Chen K., Chen Y., Hardy J., Li Y., Fu A.K.Y., Guo Q., Ip N.Y. and for the Alzheimer’s Disease Neuroimaging Initiative
Proc. Natl. Acad. Sci. USA. February 20, 2018. 115 (8) 1697-1706; published ahead of print February 5, 2018; https://doi.org/10.1073/pnas.1715554115.
[Full text] [Full text]
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development
Huang H., Lin X., Liang Z., Zhao T., Du S., Loy M.M.T., Lai K.O., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. August 15, 2017. 114 (33) E6992-E7001; published ahead of print July 31, 2017. https://doi.org/10.1073/pnas.1708240114
[Full text] [Full text]
IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline
Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016. https://doi.org/10.1073/pnas.1604032113
[Full text] [Full text] [F1000 Prime Recommended]
S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength
Zhang P., Fu W.Y., Fu A.K.Y., and Ip N.Y.
Nat. Commun. 2015 Oct 27;6:8665. doi: 10.1038/ncomms9665. [Highlighted in F1000Prime]
[Full text] [Full text] [F1000 Prime Recommended]
Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Fang W.-Q., Chen W.W., Jiang L., Liu K., Yung W.H., Fu A.K.Y., and Ip N.Y.
Cell Rep. 9(5):1635-43
[Abstract] [Full text]
Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex
Ye T., Ip J.P., Fu A.K.Y., and Ip N.Y.
Nat. Commun. 5:4826. doi: 10.1038/ncomms5826
[Abstract] [Full text]
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease
Fu A.K.Y., Hung K.W., Huang H., Gu S., Shen Y., Cheng E.Y., Ip F.C.F., Huang X, Fu W.Y., and Ip N.Y.
Proc. Natl. Acad. Sci. USA 111(27):9959-64.
[Abstract] [Full text] [Highlighted in the commentary of PNAS]
Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex
Fang W.-Q., Chen W.-W., Fu A.K.Y., and Ip N.Y.
Neuron 79:665-679. [Highlighted in F1000Prime]
[Abstract] [Full text] [Video Abstract] [F1000 Prime Recommended]
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory
Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y.
Nat. Neurosci. 15:1506-1515 [Highlighted in F1000Prime] [Highlighted in News and Views of Nat. Neurosci.]
[Abstract] [Full text] [F1000 Prime Recommended]
α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2
Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y., and Ip N.Y.
Nat. Neurosci. 15:39-47. [Highlighted in F1000Prime]
[Abstract] [Full text] [F1000 Prime Recommended]
APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity
Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y.
Nat. Neurosci. 14: 181-9. [Featured in News and Views of Nat. Neurosci.]
[Abstract] [Full text]
Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease
Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., and Ip N.Y.
Nat. Cell Biol. 13:568-579.
[Abstract] [Full text]
Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease
Wan, J., Fu, A.K.Y., Ip, F.C.F., Ng, H.K., Hugon, J., Page, G., Wang, J.H., Lai, K.O., Wu, Z., and Ip, N.Y.
J. Neurosci. 30(20): 6873-6881. [Highlighted in Alzheimer Research Forum]
[Abstract] [Full text]
Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction
Shi L., Butt B., Ip F.C.F., Dai Y., Jiang L., Yung W.H., Greenberg, M.E., Fu A.K.Y., and Ip N.Y.
Neuron 65: 204–216.
[Abstract] [Full text]
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
Fu W.Y., Chen Y., Sahin, M., Zhao X.S., Shi L., Bikoff, J.B., Lai K.O., Yung W.H., Fu A.K.Y., Greenberg, M.E., and Ip N.Y.
Nat. Neurosci. 10: 67-76. [Highlighted in Alzheimer Research Forum and in J. Cell Biol. (2007). 176(1): 5]
[Abstract] [Full text]
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons
Cheung Z.H., Chin W.H., Chen Y., Ng Y.P., and Ip N.Y.
PLoS Biol. 5(4) : 867-865.
[Abstract] [Full text]
α2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse
Shi L., Fu W.Y., Hung K.W., Porchetta, C., Hall, C., Fu A.K.Y., and Ip N.Y.
Proc. Natl. Acad. Sci. USA 104: 16347-16352.
[Abstract] [Full text]
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts
Sun L., Ma K., Wang H., Xiao F., Gao Y., Zhang W., Wang K., Gao X., Ip N.Y. and Wu Z.
J. Cell Biol. 179: 129-138.
[Abstract] [Full text]
α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner
Luo S., Chen Y., Lai K.O., Arevalo, J.C., Froehner, S., Adams, M.E., Chao M., and Ip, N.Y.
J. Cell Biol. 169: 813-824
[Abstract] [Full text]
Aberrant motor axon projection, AChR clustering and neurotransmission in cyclin-dependent kinase 5 null mice
Fu A.K.Y., Ip F.C.F., Fu W.Y., Cheng J., Wang J., Yung W.H., and Ip N.Y.
Proc. Natl. Acad. Sci. USA 102: 15224-15229.
[Abstract] [Full text]
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
Fu A.K.Y., Fu W.Y., Ng A.K.Y., Chien W.W.Y., Ng Y.P., Wang J., and Ip N.Y.
Proc. Natl. Acad. Sci. USA 101: 6728-6733.
[Abstract] [Full text] [F1000 Prime Recommended]
Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction
Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H., and Ip N.Y.
Nat. Neurosci. 4: 374-381. [Hightlighted in News & Views Nat. Neurosci.]
[Abstract] [Full text]
CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons
Ip N.Y., Boulton, T.G., Li Y., Verdi, J.M., Birren, S.J., Anderson, D.J., and Yancopoulos, G.D.
Neuron 13: 443-455.
[Abstract]
The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development
Ip N.Y., McClain, J., Barrezueta, N., Aldrich, T.H., Pan, L., Li Y., Wiegand, S.J., Friedman, B., Davis, S., and Yancopoulos, G.D.
Neuron 10: 89-102.
[Abstract]
Similarities and differences in the way neurotrophins interact with the Trks in neuronal and nonneuronal cells
Ip N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene L.A., Barbacid, M., and Yancopoulos, G.D.
Neuron 10: 137-149.
[Abstract]
Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity
Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D.
Proc. Natl. Acad. Sci. USA 89: 3060-3064.
[Full text]
CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130
Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D.
Cell 69: 1121-1132.
[Abstract]
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo
Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip, N.Y.
Neuron 9: 295-305.
[Abstract]
Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event
Ip N.Y., and Zigmond, R.E.
Nature 311: 472-474.
[Abstract]
Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms
Ip N.Y., Perlman, R.L. and Zigmond, R.E.
Proc. Natl. Acad. Sci. USA 80: 2081-2085.
[Full text]
Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion
Ip N.Y., Ho C.K. and Zigmond, R.E.
Proc. Natl. Acad. Sci. USA 79: 7566-7569.
[Full text]