Selected Publications

  • An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

    Jiang Y., Zhou X., Wong H.Y., Ouyang L., Ip F.C.F., Chau M.N.V., Lau S.F., Wu W., Wong Y.K.D., Seo H., Fu W.Y., Lai C.H.N., Chen Y., Chen Y., Tong P.S.E., Alzheimer’s Disease Neuroimaging Initiative, Mok C.T.V., Kwok C.T.V., Mok C.Y.T., Shoai M., Lehallier B., Losada P.M., O’Brien E., Porter T., Laws S.M., Hardy J., Wyss-Coray T., Masters C.L., Fu A.K.Y. and Ip N.Y.
    Nature Aging  2, 616–634 (2022).
    [Abstract]    [Full text]

    [ALZFORUM]  Receptor Decoy Raises Risk of Alzheimer's — But Only in Women  

  • Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong

    Wong H.Y., Zhong H., Zhong M., Zhou X., Chan P.Y.C., Kwok T.C.Y., Mok K., Hardy J., Ip F.C.F., Fu A.K.Y., Ip N.Y.
    J Alzheimers Dis. 2022 Apr 16. doi: 10.3233/JAD-215312. PMID: 35466936

  • Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese population

    Zhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y.
    Alzheimers Dement.   2021 Dec;17 Suppl 3:e056625. doi: 10.1002/alz.056625. PMID: 35109110
    [Abstract]    [Full text]

  • Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model

    Lau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y.
    STAR Protocols   STAR Protoc. 2021 Jan 13;2(1):100265. doi: 10.1016/j.xpro.2020.100265. eCollection 2021 Mar 19.
    [Abstract]    [Full text]

  • IL-33 ameliorates Alzheimer's diesase-like pathology and cognitive decline

    Fu A.K.Y., Hung K.W., Yuen, M.Y.F., Zhou, X., Mak, D.S.Y., Chan, I.C.W., Cheung, T.H., Zhang, B., Fu W.Y., Liew, F.Y. and Ip N.Y.
    Proc. Natl. Acad. Sci. USA.   May 10, 2016. 113 (19) E2705-E2713; published ahead of print April 18, 2016.
    [Full text]    [Full text]    [F1000 Prime Recommended]

  • S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength

    Zhang P., Fu W.Y., Fu A.K.Y., and Ip N.Y.
    Nat. Commun.   2015 Oct 27;6:8665. doi: 10.1038/ncomms9665. [Highlighted in F1000Prime]
    [Full text]    [Full text]    [F1000 Prime Recommended]

  • Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

    Fang W.-Q., Chen W.W., Jiang L., Liu K., Yung W.H., Fu A.K.Y., and Ip N.Y.
    Cell Rep.   9(5):1635-43
    [Abstract]    [Full text]

  • Cdk5-mediated phosphorylation of ​RapGEF2 controls neuronal migration in the developing cerebral cortex

    Ye T., Ip J.P., Fu A.K.Y., and Ip N.Y.
    Nat. Commun.   5:4826. doi: 10.1038/ncomms5826
    [Abstract]    [Full text]

  • Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease

    Fu A.K.Y., Hung K.W., Huang H., Gu S., Shen Y., Cheng E.Y., Ip F.C.F., Huang X, Fu W.Y., and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   111(27):9959-64.
    [Abstract]    [Full text]    [Highlighted in the commentary of PNAS]

  • TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

    Lai K.O., Wong A.S.L., Cheung M.C., Xu P., Liang Z.Y., Lok K.C., Xie H., Palko, M.E., Yung W.H., Tessarollo, L., Cheung Z.H. and Ip N.Y.
    Nat. Neurosci.   15:1506-1515   [Highlighted in F1000Prime] [Highlighted in News and Views of Nat. Neurosci.]
    [Abstract]    [Full text]    [F1000 Prime Recommended]

  • α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2

    Ip J.P., Shi L., Chen Y., Itoh Y., Fu W.Y., Betz, A., Yung W.H., Gotoh, Y., Fu A.K.Y., and Ip N.Y.
    Nat. Neurosci.   15:39-47.   [Highlighted in F1000Prime]
    [Abstract]    [Full text]    [F1000 Prime Recommended]

  • APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

    Fu A.K.Y., Hung K.W., Fu W.Y., Shen C., Chen Y., Xi, J., Lai K.O. and Ip N.Y.
    Nat. Neurosci.   14: 181-9.   [Featured in News and Views of Nat. Neurosci.]
    [Abstract]    [Full text]   

  • Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

    Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., and Ip N.Y.
    Nat. Cell Biol.   13:568-579.
    [Abstract]    [Full text]   

  • Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer's disease

    Wan, J., Fu, A.K.Y., Ip, F.C.F., Ng, H.K., Hugon, J., Page, G., Wang, J.H., Lai, K.O., Wu, Z., and Ip, N.Y.
    J. Neurosci.   30(20): 6873-6881.  [Highlighted in Alzheimer Research Forum]
    [Abstract]    [Full text]   

  • Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction

    Shi L., Butt B., Ip F.C.F., Dai Y., Jiang L., Yung W.H., Greenberg, M.E., Fu A.K.Y., and Ip N.Y.
    Neuron   65: 204–216.
    [Abstract]    [Full text]   

  • Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons

    Cheung Z.H., Chin W.H., Chen Y., Ng Y.P., and Ip N.Y.
    PLoS Biol.   5(4) : 867-865.
    [Abstract]    [Full text]   

  • α2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse

    Shi L., Fu W.Y., Hung K.W., Porchetta, C., Hall, C., Fu A.K.Y., and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   104: 16347-16352.
    [Abstract]    [Full text]   

  • JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts

    Sun L., Ma K., Wang H., Xiao F., Gao Y., Zhang W., Wang K., Gao X., Ip N.Y. and Wu Z.
    J. Cell Biol.   179: 129-138.
    [Abstract]    [Full text]   

  • α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner

    Luo S., Chen Y., Lai K.O., Arevalo, J.C., Froehner, S., Adams, M.E., Chao M., and Ip, N.Y.
    J. Cell Biol.   169: 813-824
    [Abstract]    [Full text]   

  • Aberrant motor axon projection, AChR clustering and neurotransmission in cyclin-dependent kinase 5 null mice

    Fu A.K.Y., Ip F.C.F., Fu W.Y., Cheng J., Wang J., Yung W.H., and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   102: 15224-15229.
    [Abstract]    [Full text]   

  • Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity

    Fu A.K.Y., Fu W.Y., Ng A.K.Y., Chien W.W.Y., Ng Y.P., Wang J., and Ip N.Y.
    Proc. Natl. Acad. Sci. USA   101: 6728-6733.
    [Abstract]    [Full text]    [F1000 Prime Recommended]

  • Cdk5 is involved in neuregulin-induced acetylcholine receptor expression at the neuromuscular junction

    Fu A.K.Y., Fu W.Y., Cheung J., Tsim K.W.K., Ip F.C.F., Wang J.H., and Ip N.Y.
    Nat. Neurosci.   4: 374-381.  [Hightlighted in News & Views Nat. Neurosci.]
    [Abstract]    [Full text]   

  • CNTF, FGF and NGF collaborate to drive the terminal differentiation of MAH cells into post-mitotic neurons

    Ip N.Y., Boulton, T.G., Li Y., Verdi, J.M., Birren, S.J., Anderson, D.J., and Yancopoulos, G.D.
    Neuron   13: 443-455.

  • The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

    Ip N.Y., McClain, J., Barrezueta, N., Aldrich, T.H., Pan, L., Li Y., Wiegand, S.J., Friedman, B., Davis, S., and Yancopoulos, G.D.
    Neuron   10: 89-102.

  • Similarities and differences in the way neurotrophins interact with the Trks in neuronal and nonneuronal cells

    Ip N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene L.A., Barbacid, M., and Yancopoulos, G.D.
    Neuron   10: 137-149.

  • Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution and receptor specificity

    Ip N.Y., Ibanez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa III, R., Squinto, S.P., Persson, H., and Yancopoulos, G.D.
    Proc. Natl. Acad. Sci. USA   89: 3060-3064.
    [Full text]   

  • CNTF and LIF act on neuronal cells via shared signalling pathways that involve the IL-6 signal transducing receptor component gp130

    Ip N.Y., Nye, S.H., Boulton, T. G., Davis, S., Taga, T., Li, Y., Birren, S.J., Yasukawa, K., Kishimoto, T., Anderson, D.J., Stahl, N., and Yancopoulos, G.D.
    Cell   69: 1121-1132.

  • Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

    Friedman, B., Scherer, S.S., Rudge, J.S., Helgren, M., Morrisey, D., McClain, J., Wang, D.-W., Wiegand, S.J., Furth, M.E., Lindsay, R.M. and Ip, N.Y.
    Neuron    9: 295-305.

  • Pattern of presynaptic nerve activity can determine the type of neurotransmitter regulating a postsynaptic event

    Ip N.Y., and Zigmond, R.E.
    Nature    311: 472-474.

  • Acute transsynaptic regulation of tyrosine 3-monooxygenase activity in the superior cervical ganglion: evidence for both cholinergic and noncholinergic mechanisms

    Ip N.Y., Perlman, R.L. and Zigmond, R.E.
    Proc. Natl. Acad. Sci. USA   80: 2081-2085.
    [Full text]   

  • Secretin and vasoactive intestinal peptide acutely increase tyrosine 3-monooxygenase activity in the rat superior cervical ganglion

    Ip N.Y., Ho C.K. and Zigmond, R.E.
    Proc. Natl. Acad. Sci. USA   79: 7566-7569.
    [Full text]